ArticleBiomedical optics express2016
Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Luminescence lifetime imaging of three-dimensional biological objects.Journal of cell science · 2021Article
- Enhanced detection of oral dysplasia by structured illumination fluorescence lifetime imaging microscopy.Scientific reports · 2021Article
- Direct frequency domain fluorescence lifetime imaging using field programmable gate arrays for real time processing.The Review of scientific instruments · 2020Article
- Fiber-based platform for synchronous imaging of endogenous and exogenous fluorescence of biological tissue.Optics letters · 2019Article
- Automated detection of superficial macrophages in atherosclerotic plaques using autofluorescence lifetime imaging.Atherosclerosis · 2019Article
- Extended Blind End-member and Abundance Extraction for Biomedical Imaging Applications.IEEE access : practical innovations, open solutions · 2019Article
- Label-free assessment of carotid artery biochemical composition using fiber-based fluorescence lifetime imaging.Biomedical optics express · 2018Article
- Multispectral analog-mean-delay fluorescence lifetime imaging combined with optical coherence tomography.Biomedical optics express · 2018Article
- Simultaneous, label-free, multispectral fluorescence lifetime imaging and optical coherence tomography using a double-clad fiber.Optics letters · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Multimodal imaging probes a variety of tissue properties in a single image acquisition by merging complimentary imaging technologies. Exploiting synergies amongst the data, algorithms can be developed that lead to better tissue characterization than could be accomplished by the constituent imaging modalities taken alone. The combination of optical coherence tomography (OCT) with fluorescence lifetime imaging microscopy (FLIM) provides access to detailed tissue morphology and local biochemistry. The optical system described here merges 1310 nm swept-source OCT with time-domain FLIM having excitation at 355 and 532 nm. The pulses from 355 and 532 nm lasers have been interleaved to enable simultaneous acquisition of endogenous and exogenous fluorescence signals, respectively. The multimodal imaging system was validated using tissue phantoms. Nonspecific tagging with Alexa Flour 532 in a Watanbe rabbit aorta and active tagging of the LOX-1 receptor in human coronary artery, demonstrate the capacity of the system for simultaneous acquisition of OCT, endogenous FLIM, and exogenous FLIM in tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.