Evidence map›Paper›PMID 27699061›Full record

ArticleRegenerative biomaterials2016

Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior.

Shenglian Yao, Huiying Liu, Shukui Yu, Yuanyuan Li, Xiumei Wang, Luning Wang

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 44 citations in OpenAlex.

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  15. Poly(lactic-co-glycolic acid) devices: Production and applications for sustained protein delivery.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Shenglian YaoSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China,; State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Huiying LiuDepartment of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Shukui YuInstitute for Neuroscience, Capital Medical University, Beijing 100069, China.
Yuanyuan LiState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China,; Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Xiumei WangState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Luning WangSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
State Key Laboratory of New Ceramics and Fine ProcessingCapital Medical University · CNDalian Medical University · CNTsinghua University · CNUniversity of Science and Technology Beijing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system. In this study, two kind of aqueous model drugs with different molecule weight, Congo red and albumin from bovine serum (BSA) were nano-encapsulated in poly (dl-lactic-co-glycolic acid) (PLGA) microspheres by emulsion electrospray. In the preparation process, the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution. The emulsion was then electrosprayed to fabricate drug-nanoencapsulated PLGA microspheres. The morphology of the PLGA microspheres was affected by the volume ratio of aqueous drug phase and organic PLGA phase (

Indexed as

controlled drug releasedrug nanoencapsulationemulsion electrosprayPLGA microspheres

Identifiers

PMID27699061
PMCPMC5043157
OpenAlexW2521199450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.