ArticleRegenerative biomaterials2016
Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo.
Article in Regenerative biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Development of Hydroxyapatite as a Bone Implant Biomaterial for Triggering Osteogenesis.European journal of dentistry · 2026Article
- Hydroxyapatite-cellulose composites: properties, fabrication methods, and applications.Journal of materials science. Materials in medicine · 2026Review
- Bicontinuous Interconnected Porous Biomaterials for Tissue Engineering and Regeneration.Small science · 2025Article
- Impact of Particle Size and Sintering Temperature on Calcium Phosphate Gyroid Structure Scaffolds for Bone Tissue Engineering.Journal of functional biomaterials · 2024Article
- Three-Dimensional Printing of Drug-Eluting Implantable PLGA Scaffolds for Bone Regeneration.Bioengineering (Basel, Switzerland) · 2024Article
- Bio-functional hydroxyapatite-coated 3D porous polyetherketoneketone scaffold for enhanced osteogenesis and osteointegration in orthopedic applications.Regenerative biomaterials · 2024Article
- A novel porous hydroxyapatite scaffold (pHAMG) enhances angiogenesis and osteogenesis around dental implants by regulating the immune microenvironment.Clinical oral investigations · 2023Article
- Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite.International journal of molecular sciences · 2023Review
- Pore size-mediated macrophage M1 to M2 transition affects osseointegration of 3D-printed PEEK scaffolds.International journal of bioprinting · 2023Article
- Study on βTCP/P(3HB) Scaffolds-Physicochemical Properties and Biological Performance in Low Oxygen Concentration.International journal of molecular sciences · 2022Article
- Evaluation of calcium phosphate-coated polycaprolactone/graphene oxide scaffold with macro- and microporous structure for bone tissue engineering.In vitro models · 2022Article
- Improved cell seeding efficiency and cell distribution in porous hydroxyapatite scaffolds by semi-dynamic method.Cell and tissue banking · 2022Article
- Biological activity of a vascular endothelial cell-hydroxyapatite orbital implant complex: An experimental study.Experimental and therapeutic medicine · 2022Article
- Integrating pore architectures to evaluate vascularization efficacy in silicate-based bioceramic scaffolds.Regenerative biomaterials · 2022Article
- Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation.Bioactive materials · 2021Article
- The effect of macropore size of hydroxyapatite scaffold on the osteogenic differentiation of bone mesenchymal stem cells under perfusion culture.Regenerative biomaterials · 2021Article
- [Research progress ofZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Review
- Application of biomaterials for the repair and treatment of osteonecrosis of the femoral head.Regenerative biomaterials · 2020Review
- Article
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8 authors.
Funding
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Abstract
The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes. In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs, hydroxyapatite (HA) scaffolds with three different macro-pore sizes of 500-650, 750-900 and 1100-1250 µm were prepared via sugar spheres-leaching process, which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant. The permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore sizes. The cell growth in three scaffolds was not affected by the macro-pore sizes. The in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed bone. The scaffold with macro-pore sizes of 750-900 µm exhibited much faster angiogenesis and osteogenesis, and much more uniformly distribution of new bone than those with other macro-pore sizes. This work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis.
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