Evidence map›Paper›PMID 27699057›Full record

ArticleRegenerative biomaterials2016

Controlling the strontium-doping in calcium phosphate microcapsules through yeast-regulated biomimetic mineralization.

Miaojun Huang, Tianjie Li, Ting Pan, Naru Zhao, Yongchang Yao, Zhichen Zhai, Jiaan Zhou, Chang Du, Yingjun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miaojun HuangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; ; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China.
Tianjie LiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; ; Ministry of Education Key Laboratory of Biomedical Materials Science and Engineering, Guangzhou 510006, China.
Ting PanSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; ; Ministry of Education Key Laboratory of Biomedical Materials Science and Engineering, Guangzhou 510006, China.
Naru ZhaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; ; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Yongchang YaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Zhichen ZhaiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Jiaan ZhouNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China.
Chang DuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; ; Ministry of Education Key Laboratory of Biomedical Materials Science and Engineering, Guangzhou 510006, China.
Yingjun WangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; ; National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yeast cells have controllable biosorption on metallic ions during metabolism. However, few studies were dedicated to using yeast-regulated biomimetic mineralization process to control the strontium-doped positions in calcium phosphate microcapsules. In this study, the yeast cells were allowed to pre-adsorb strontium ions metabolically and then served as sacrificing template for the precipitation and calcination of mineral shell. The pre-adsorption enabled the microorganism to enrich of strontium ions into the inner part of the microcapsules, which ensured a slow-release profile of the trace element from the microcapsule. The co-culture with human marrow stromal cells showed that gene expressions of alkaline phosphatase and Collagen-I were promoted. The promotion of osteogenic differentiation was further confirmed in the 3D culture of cell-material complexes. The strategy using living microorganism as 'smart doping apparatus' to control incorporation of trace element into calcium phosphate paved a pathway to new functional materials for hard tissue regeneration.

Indexed as

biotemplatecalcium phosphatestrontiumyeast

Identifiers

PMID27699057
PMCPMC5043151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.