Evidence map›Paper›PMID 27698944›Full record

ArticleTheranostics2016

Gelatin-based Hydrogel Degradation and Tissue Interaction

Christoph Tondera, Sandra Hauser, Anne Krüger-Genge, Friedrich Jung, Axel T Neffe, Andreas Lendlein, Robert Klopfleisch, Jörg Steinbach, Christin Neuber, Jens Pietzsch

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
  2. ACS omega · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Long-Term Morphological Changes of Crosslinked Gelatin Stent.Clinical & experimental ophthalmology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Digital Light Processing ofMaterials (Basel, Switzerland) · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christoph TonderaHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany;; Technische Universität Dresden, Department of Chemistry and Food Chemistry, Dresden, Germany.
Sandra HauserHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany.
Anne Krüger-GengeInstitute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Friedrich JungInstitute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany;; Helmholtz Virtual Institute "Multifunctional Biomaterials for Medicine", Teltow and Berlin.
Axel T NeffeInstitute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany;; Helmholtz Virtual Institute "Multifunctional Biomaterials for Medicine", Teltow and Berlin.
Andreas LendleinInstitute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany;; Helmholtz Virtual Institute "Multifunctional Biomaterials for Medicine", Teltow and Berlin.
Robert KlopfleischFreie Universität Berlin, Institute of Veterinary Pathology, Berlin, Germany.
Jörg SteinbachTechnische Universität Dresden, Department of Chemistry and Food Chemistry, Dresden, Germany;; Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.
Christin NeuberHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany.
Jens PietzschHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radiopharmaceutical and Chemical Biology, Dresden, Germany;; Technische Universität Dresden, Department of Chemistry and Food Chemistry, Dresden, Germany.
Helmholtz-Zentrum Hereon · DEHelmholtz-Zentrum Dresden-Rossendorf · DETU Dresden · DEFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogels based on gelatin have evolved as promising multifunctional biomaterials. Gelatin is crosslinked with lysine diisocyanate ethyl ester (LDI) and the molar ratio of gelatin and LDI in the starting material mixture determines elastic properties of the resulting hydrogel. In order to investigate the clinical potential of these biopolymers, hydrogels with different ratios of gelatin and diisocyanate (3-fold (G10_LNCO3) and 8-fold (G10_LNCO8) molar excess of isocyanate groups) were subcutaneously implanted in mice (uni- or bilateral implantation). Degradation and biomaterial-tissue-interaction were investigated

Indexed as

ProteolysisAnimalsAutoradiographyGelatinHistocytochemistryHydrogel, Polyethylene Glycol DimethacrylateMagnetic Resonance ImagingMice, NudeOptical ImagingPositron-Emission TomographySerumGelatinHydrogel, Polyethylene Glycol DimethacrylateAutoradiography ex vivoBiomaterialsComputed tomographyMagnetic resonance imagingOptical imagingPositron emission tomography.

Identifiers

PMID27698944
PMCPMC5039684
OpenAlexW2518826940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.