Evidence map›Paper›PMID 27698933›Full record

ArticleJournal of Cancer2016

Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.

Robert Fred Henry Walter, Claudia Vollbrecht, Robert Werner, Thomas Mairinger, Jan Schmeller, Elena Flom, Jeremias Wohlschlaeger, Nikolaos Barbetakis, Dimitrios Paliouras, Fotios Chatzinikolaou and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Robert Fred Henry WalterRuhrlandklinik, West German Lung Centre, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;; Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Claudia VollbrechtInstitute of Pathology, Division of Molecular Pathology, Charité, Berlin, Germany.
Robert WernerDepartment of Pathology, Helios Klinikum Emil von Behring, Berlin Germany.
Thomas MairingerDepartment of Pathology, Helios Klinikum Emil von Behring, Berlin Germany.
Jan SchmellerInstitute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Elena FlomRuhrlandklinik, West German Lung Centre, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jeremias WohlschlaegerInstitute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;; Institute of Pathology, Ev.-Luth. Diakonissenkrankenhaus Flensburg, Flensburg, Germany.
Nikolaos BarbetakisThoracic Surgery Department, Theagenio Cancer Hospital, Thessaloniki, Greece.
Dimitrios PaliourasThoracic Surgery Department, Theagenio Cancer Hospital, Thessaloniki, Greece.
Fotios ChatzinikolaouPathology Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.
Vasilis AdamidisPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kosmas TsakiridisPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Paul ZarogoulidisPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Georgia TrakadaDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Daniel Christian ChristophInstitute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Kurt Werner SchmidInstitute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Fabian Dominik MairingerInstitute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DETheageneio General Hospital · GRG. Papanikolaou General Hospital · GRHelios Klinikum Emil von Behring · DEAlexandra Hospital · GRAristotle University of Thessaloniki · GRCharité - Universitätsmedizin Berlin · DEDiakonissenkrankenhaus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalignant pleural mesothelioma (MPM) is a rare, predominantly asbestos-related and biologically highly aggressive tumour leading to a dismal prognosis. Multimodality therapy consisting of platinum-based chemotherapy is the treatment of choice. The reasons for the rather poor efficacy of platinum compounds remain largely unknown. MATERIAL AND

methodsFor this exploratory mRNA study, 24 FFPE tumour specimens were screened by digital gene expression analysis. Based on data from preliminary experiments and recent literature, a total of 366 mRNAs were investigated using a Custom CodeSet from NanoString. All statistical analyses were calculated with the R i386 statistical programming environment.

results

conclusionDNA-damage response plays a crucial role in response to platin-based chemotherapeutic regimes. In particular,

Indexed as

digital gene expression analysisDNA-damage repairNanoString nCounterplatin-based chemotherapy.pleural mesothelioma

Identifiers

PMID27698933
PMCPMC5039377
OpenAlexW2529848582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.