Evidence map›Paper›PMID 27698866›Full record

ArticleOncology letters2016

4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation.

Yuanyuan Liu, Jing Gao, Shuangsheng Huang, Lamei Hu, Zhiqiang Wang, Zheyuan Wang, Xiao Chen, Xiaoyu Zhang, Wenguang Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yuanyuan LiuCollege of Basic Medicine, Key Laboratory of Preclinical Study for New Drugs of Gansu, Lanzhou University, Lanzhou, Gansu 730000, P.R. China; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, P.R. China.
Jing GaoClinical Laboratory, Affiliated Hospital of Medical College of Northwest University for Nationalities, Lanzhou, Gansu 730030, P.R. China.
Shuangsheng HuangClinical Laboratory, Affiliated Hospital of Medical College of Northwest University for Nationalities, Lanzhou, Gansu 730030, P.R. China.
Lamei HuCollege of Basic Medicine, Key Laboratory of Preclinical Study for New Drugs of Gansu, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Zhiqiang WangCollege of Basic Medicine, Key Laboratory of Preclinical Study for New Drugs of Gansu, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Zheyuan WangDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China.
Xiao ChenDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China.
Xiaoyu ZhangCollege of Basic Medicine, Key Laboratory of Preclinical Study for New Drugs of Gansu, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Wenguang LiCollege of Basic Medicine, Key Laboratory of Preclinical Study for New Drugs of Gansu, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Lanzhou University · CNNorthwest Minzu University · CNLanzhou University Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) are involved in the signaling pathway and are triggered by angiogenic factors, including vascular endothelial growth factor and angiopoietins. 4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl (4-ISO-Tempo) is one of the nitroxides that exhibits antioxidant activity. However, the anti-angiogenic effect of 4-ISO-Tempo remains unknown. The aim of this study was to investigate the effect of 4-ISO-Tempo on tumor proliferation and angiogenesis as well as its underlying mechanisms. Our results revealed that 4-ISO-Tempo significantly inhibited the viability of neoplastic and endothelial cells. Furthermore, the effective concentration of 4-ISO-Tempo on human microvascular endothelial cell 1 (HMEC-1) was lower than that on human lung adenocarcinoma A549 and human colon cancer SW620 cells. This suggested that endothelial cells were more sensitive to 4-ISO-Tempo than tumor cells. Furthermore, we demonstrated that 4-ISO-Tempo also suppressed secretion of matrix metalloproteinase (MMP)-2 and MMP-9, and migration and tube formation of HMEC-1 cells. The mechanism is attributed to the decreasing ROS generation and further phosphorylation of vascular endothelial growth factor receptor 2 and Tie2. Our findings suggest that 4-ISO-Tempo should be investigated for its usefulness in anti-angiogenesis therapies.

Indexed as

24-isothiocyanate-266-tetramethyl piperidinooxylangiogenesisreactive oxygen speciesTie2vascular endothelial growth factor receptor 2

Identifiers

PMID27698866
PMCPMC5038461
OpenAlexW2498295489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.