Evidence map›Paper›PMID 27698858›Full record

ArticleOncology letters2016

Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions.

Therese Högfeldt, Crystal Jaing, Kevin Mc Loughlin, James Thissen, Shea Gardner, Abeer A Bahnassy, Baback Gharizadeh, Joachim Lundahl, Anders Österborg, Anna Porwit and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Therese HögfeldtDepartment of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
Crystal JaingChemistry, Materials, Earth and Life Sciences, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Kevin Mc LoughlinComputation, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
James ThissenChemistry, Materials, Earth and Life Sciences, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Shea GardnerComputation, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Abeer A BahnassyDepartment of Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Baback GharizadehStanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.
Joachim LundahlDepartment of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Anders ÖsterborgDepartment of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
Anna PorwitDepartment of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
Abdel-Rahman N ZekriDepartment of Cancer Biology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Hussein M KhaledDepartment of Medical Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Håkan MellstedtDepartment of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
Ali MoshfeghDepartment of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
Karolinska Institutet · SELawrence Livermore National Laboratory · USCairo University · EGKarolinska University Hospital · SEStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL) in adults, accounts for approximately 30-40% of newly diagnosed lymphomas worldwide. Environmental factors, such as viruses and bacteria, may contribute to cancer development through chronic inflammation and the integration of oncogenes, and have previously been indicated in cervical cancer, hepatocellular carcinoma, gastric cancer and lymphoproliferative disorders. In the present study, the presence of microbial agents was analyzed in the lymphoma tissue of patients with activated B-cell like (ABC) DLBCL. The present study compared two groups of patients from geographically varied regions that possess a difference in the prevalence of viral and other microbial agents. The patient populations were from Sweden (a low endemic infectious disease region) and Egypt (a high endemic infectious disease region). A differential expression of several viruses in lymphoma tissues was noted when comparing Swedish and Egyptian patients. JC polyomavirus (JCV) was detected in Swedish and Egyptian patients and, uniquely, the complete hepatitis B virus (HBV) genome was detected only in Egyptian lymphoma patients. None of these viruses were detected in control lymph tissues from Sweden or Egypt. In total, 38% of the Egyptian patients were found to have HBV surface antigens (HBsAgs) in their serum; however, HBsAgs were not found in any of the Swedish patients. The percentage of serum HBsAgs in Egyptian patients with ABC DLBCL was significantly increased compared with the general Egyptian population (P<0.05). The present study may support a notion that viral agents, including JCV and HBV, may be involved in the tumorigenesis of DLBCL in regions of high infectious disease.

Indexed as

gene arrayhepatitis B viruslymphoma and Hodgkin diseasemolecular geneticsvirus

Identifiers

PMID27698858
PMCPMC5038175
OpenAlexW2517431052

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.