ArticleExperimental and therapeutic medicine2016
Multimodal imaging findings of SAPHO syndrome with no skin lesions: A report of three cases and review of the literature.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- SAPHO-like bone scintigraphy in diffuse idiopathic skeletal hyperostosis: a case report.Frontiers in medicine · 2026Article
- Review
- SAPHO Syndrome Misdiagnosed as Spinal Infection: A Case Series.International medical case reports journal · 2025Article
- The clinical characteristics and prognosis of patients with SAPHO syndrome--a real-world cohort study.Clinical rheumatology · 2024Article
- SAPHO syndrome after COVID-19 vaccination complicated with thyroid function abnormalities: a case report and literature review.Immunologic research · 2023Review
- Bull's Head Sign.JMA journal · 2022Article
- Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome of femoral neoplasm-like onset: a case-based review.The Journal of international medical research · 2021Article
- Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) Syndrome: Clinical and Therapeutic Aspects.Cureus · 2021Article
- The comparison analysis of clinical and radiological features in SAPHO syndrome.Clinical rheumatology · 2021Article
- Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: review and update.Therapeutic advances in musculoskeletal disease · 2020Review
- Bull’s Head Sign in a Patient with SAPHO SyndromeBalkan medical journal · 2019Article
- SAPHO syndrome with pathological fractures of vertebral bodies: a case report.BMC musculoskeletal disorders · 2019Article
- Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report.Medicine · 2018Article
- Chest wall - underappreciated structure in sonography. Part II: Non-cancerous lesions.Journal of ultrasonography · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years. The second case was a 62-year-old female with arthritis in the larger joints for 5 years, particularly on the right thoracic area. The third case was a 44-year-old male who exhibited a slight bulge accompanied by pain in the upper anterior chest wall for 4 years. All of them lacked cutaneous lesions. CT demonstrated sclerosis and hyperostosis with subchondral erosions in the sternocostoclavicular joints. MRI revealed bone marrow edema that was slightly hypointense on T1-weighted imaging, and hyperintense on T2-weighted imaging. Typical 'bull head' signs were observed in bone scintigraphy images. The present case study demonstrated that SAPHO syndrome should be suspected in patients with multifocal osteitis or arthritis affecting the chest wall that lack skin manifestations. Multimodal imaging modalities in combination are helpful for SAPHO diagnosis.
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