ArticleExperimental and therapeutic medicine2016
Diagnosing pyogenic, brucella and tuberculous spondylitis using histopathology and MRI: A retrospective study.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Magnetic resonance imaging features for differentiating tuberculous from pyogenic spondylitis: a meta-analysis.Skeletal radiology · 2024Pooled it
- Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part II: MRI/CT Features, Prediction Models, and the Role of PET/CT-A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Differentiating Tuberculous and Pyogenic Spondylodiscitis: Part I-Epidemiology, Clinical Features, Laboratory Markers, and Tissue-Based Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- Iron overload disrupts bone homeostasis via TfR1-dependent ferroptosis and cGAS/STING-driven pyroptosis in pyogenic spondylitis.Frontiers in immunology · 2026Article
- Imaging clues for the diagnosis of various pathogenic causes of infectious spondylitis.Skeletal radiology · 2025Review
- The regulating markers for Brucella spondylitis and tuberculous spondylitis.BMC infectious diseases · 2025Article
- A localized vertebral infection model of pyogenic spondylitis induced byFrontiers in medicine · 2025Article
- Deep Learning for Discrimination of Early Spinal Tuberculosis from Acute Osteoporotic Vertebral Fracture on CT.Infection and drug resistance · 2025Article
- Preliminary Retrospective Analysis of X-Ray, CT, and MRI Imaging Features of Brucellar Spondylodiscitis Diagnosis.Journal of inflammation research · 2025Article
- Clinical Features and Treatment Differences Among Tuberculous, Brucellosis, and Pyogenic Spondylitis: A Cohort Study.Infection and drug resistance · 2025Article
- A diagnostic model for differentiating tuberculous spondylodiscitis from pyogenic spondylodiscitis based on pathogen-confirmed patients.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Tuberculous Spondylitis and Paravertebral Abscess Formation Following Vertebroplasty: A Case Report and Review of the Literature.Infection and drug resistance · 2024Article
- A Novel Differentiation Nomogram Model for Brucellar Spondylitis and Tuberculous Spondylitis.Infection and drug resistance · 2024Article
- Discitis-osteomyelitis: optimizing results of percutaneous sampling.Skeletal radiology · 2023Review
- Brucellosis of the spine - A global public health problem - An analysis of 37 patients from a 'high risk' region.Journal of clinical orthopaedics and trauma · 2023Article
- The Potential of a CT-Based Machine Learning Radiomics Analysis to Differentiate Brucella and Pyogenic Spondylitis.Journal of inflammation research · 2023Article
- Imaging update in spinal tuberculosis.Journal of clinical orthopaedics and trauma · 2022Review
- [Pathophysiology and MRI Findings of Infectious Spondylitis and the Differential Diagnosis].Taehan Yongsang Uihakhoe chi · 2021Review
- Differentiating brucella spondylitis from tuberculous spondylitis by the conventional MRI and MR T2 mapping: a prospective study.European journal of medical research · 2021Article
- The Angiopoietin-like protein 4: a promising biomarker to distinguish brucella spondylitis from tuberculous spondylitis.Clinical rheumatology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study examined the histopathological and magnetic resonance imaging (MRI) features of pyogenic, brucella and tuberculous spondylitis (PS, BS and TS, respectively). A total of 22 PS, 20 BS and 20 TS patients were included in the study. Histopathological examination was used to assess the lesion structure and composition, and the MRI observation identified the lesion location and signal features. The following histopathological and MRI features were identified significantly more in patients with PS than in patients with BS and TS: Predominant neutrophil infiltration, abnormal intervertebral disk signal, lesions on the ventral and lateral sides of the vertebral bodies, and thick and irregular abscess walls. The following histopathological and MRI features were identified significantly more in patients with BS than in patients with PS and TS: Predominant lymphocyte infiltration, new bone formation, epithelioid granuloma, lesions on the ventral sides of the vertebral bodies, no, or very mild, vertebral body deformation, no abnormal paraspinal soft tissue signal, no intraosseous or paraspinal abscesses, and thin and irregular abscess walls. The following histopathological and MRI features were identified significantly more in patients with TS than in patients with BS and PS: Sequestrum, Langerhans giant cells, caseous necrosis, lesions primarily in the thoracic region and on the lateral sides of the vertebral bodies, no obvious intervertebral disk damage, obvious vertebral body deformation, abnormal paraspinal soft tissue signal, intraosseous or paraspinal abscesses, and thin and smooth abscess walls. In conclusion, it can be suggested that these significant differences in histopathological and MRI features between the three different types of spondylitis may contribute towards the differential diagnosis of the diseases.
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