Evidence map›Paper›PMID 27698614›Full record

ReviewThe Yale journal of biology and medicine2016

Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.

Xiaomei Cong, Wanli Xu, Rachael Romisher, Samantha Poveda, Shaina Forte, Angela Starkweather, Wendy A Henderson

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in The Yale journal of biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2018
    Pooled it
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  8. Observational
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  19. The Role of MicroRNA and Microbiota in Depression and Anxiety.Frontiers in behavioral neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaomei CongSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA; Institute for Systems Genomics, University of Connecticut, Farmington, Connecticut, USA.
Wanli XuSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
Rachael RomisherSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
Samantha PovedaSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
Shaina ForteSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
Angela StarkweatherSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
Wendy A HendersonDigestive Disorders Unit, Biobehavioral Branch, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Symptom Distress Mechanisms in Digestive DisordersZIANR000018 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI HENDERSON, WENDY · 2009 to 2019
$5.2M
Promoting Self-Management of Spinal Pain in AdolescentsP20NR016605 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI MCGRATH, JACQUELINE M. · 2016 to 2020
$1.7M
Early Life Experience Imprints Gut Microbiome in Preterm InfantsK23NR014674 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2013 to 2015
$396k
Intramural NIH HHS ZIA NR000018NINR NIH HHS K23 NR014674NINR NIH HHS P20 NR016605
6 · The paper itself

Abstract

The development of the neonatal gut microbiome is influenced by multiple factors, such as delivery mode, feeding, medication use, hospital environment, early life stress, and genetics. The dysbiosis of gut microbiota persists during infancy, especially in high-risk preterm infants who experience lengthy stays in the Neonatal intensive care unit (NICU). Infant microbiome evolutionary trajectory is essentially parallel with the host (infant) neurodevelopmental process and growth. The role of the gut microbiome, the brain-gut signaling system, and its interaction with the host genetics have been shown to be related to both short and long term infant health and bio-behavioral development. The investigation of potential dysbiosis patterns in early childhood is still lacking and few studies have addressed this host-microbiome co-developmental process. Further research spanning a variety of fields of study is needed to focus on the mechanisms of brain-gut-microbiota signaling system and the dynamic host-microbial interaction in the regulation of health, stress and development in human newborns.

Indexed as

Infant HealthAnimalsBrainGastrointestinal MicrobiomeHumansBrain-Gut-Microbiota AxisEarly lifeGut MicrobiomeHost-Microbial GenomicsInfant

Identifiers

PMID27698614
PMCPMC5045139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.