Evidence map›Paper›PMID 27698491›Full record

ArticleScientific reports2016

Escherichia coli Braun Lipoprotein (BLP) exhibits endotoxemia - like pathology in Swiss albino mice.

Chikkamenahalli Lakshminarayana Lakshmikanth, Shancy Petsel Jacob, Avinash Kundadka Kudva, Calivarathan Latchoumycandane, Puttaraju Srikanta Murthy Yashaswini, Mosale Seetharam Sumanth, Cassiano F Goncalves-de-Albuquerque, Adriana R Silva, Sridevi Annapurna Singh, Hugo C Castro-Faria-Neto and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Cell surface (Amsterdam, Netherlands) · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Chikkamenahalli Lakshminarayana LakshmikanthDepartment of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore - 570 006, Karnataka, India.
Shancy Petsel JacobDepartment of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore - 570 006, Karnataka, India.
Avinash Kundadka KudvaDepartment of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, 115 Henning Building, The Pennsylvania State University, University Park, PA 16802, USA.
Calivarathan LatchoumycandaneDepartment of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
Puttaraju Srikanta Murthy YashaswiniDepartment of Protein Chemistry &Technology, Central Food Technological Research Institute/CSIR, Mysore - 570 020, Karnataka, India.
Mosale Seetharam SumanthDepartment of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore - 570 006, Karnataka, India.
Cassiano F Goncalves-de-AlbuquerqueLaboratótio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21045-900, Brazil.
Adriana R SilvaLaboratótio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21045-900, Brazil.
Sridevi Annapurna SinghDepartment of Protein Chemistry &Technology, Central Food Technological Research Institute/CSIR, Mysore - 570 020, Karnataka, India.
Hugo C Castro-Faria-NetoLaboratótio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21045-900, Brazil.
Sandeep Kumble PrabhuDepartment of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, 115 Henning Building, The Pennsylvania State University, University Park, PA 16802, USA.
Thomas M McIntyreDepartment of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
Gopal Kedihithlu MaratheDepartment of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore - 570 006, Karnataka, India.
University of Mysore · INFundação Oswaldo Cruz · BRCentral Food Technological Research Institute · INCleveland Clinic Lerner College of Medicine · USPennsylvania State University · US

Funding

Cellular Selenium Status and PGJ2 Metabolism (PA-17-078 supplement 2017)R01DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2008 to 2018
$2.5M
Targeting Leukemia Stem Cells with Dietary SeleniumR01CA162665 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2012 to 2016
$1.5M
NCI NIH HHS R01 CA162665NIDDK NIH HHS R01 DK077152
6 · The paper itself

Abstract

The endotoxin lipopolysaccharide (LPS) promotes sepsis, but bacterial peptides also promote inflammation leading to sepsis. We found, intraperitoneal administration of live or heat inactivated E. coli JE5505 lacking the abundant outer membrane protein, Braun lipoprotein (BLP), was less toxic than E. coli DH5α possessing BLP in Swiss albino mice. Injection of BLP free of LPS purified from E. coli DH5α induced massive infiltration of leukocytes in lungs and liver. BLP activated human polymorphonuclear cells (PMNs) ex vivo to adhere to denatured collagen in serum and polymyxin B independent fashion, a property distinct from LPS. Both LPS and BLP stimulated the synthesis of platelet activating factor (PAF), a potent lipid mediator, in human PMNs. In mouse macrophage cell line, RAW264.7, while both BLP and LPS similarly upregulated TNF-α and IL-1β mRNA; BLP was more potent in inducing cyclooxygenase-2 (COX-2) mRNA and protein expression. Peritoneal macrophages from TLR2

Indexed as

AnimalsBacterial Outer Membrane ProteinsCell AdhesionCyclooxygenase 2EndotoxemiaEscherichia coli ProteinsGene Expression RegulationHumansInterleukin-1betaLipopolysaccharidesLipoproteinsLiverLungMacrophages, PeritonealMiceMice, Inbred C57BLBacterial Outer Membrane ProteinsCyclooxygenase 2Escherichia coli ProteinsIL1B protein, humanInterleukin-1betaLipopolysaccharidesLipoproteinsPeroxidasePlatelet Activating FactorPTGS2 protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID27698491
PMCPMC5048175
OpenAlexW2528948463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.