ArticleScientific reports2016
Measuring cell surface area and deformability of individual human red blood cells over blood storage using quantitative phase imaging.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Investigation of Red Blood Cell Properties on Impedance Signatures Generated in a Coulter Counter.International journal for numerical methods in biomedical engineering · 2026Article
- 3D quantitative phase imagingRSC advances · 2025Article
- Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Biophysical profiling of red blood cells from thin-film blood smears using deep learning.Heliyon · 2024Article
- Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip.Micromachines · 2023Article
- Biophysical Profiling of Sickle Cell Disease Using Holographic Cytometry and Deep Learning.International journal of molecular sciences · 2023Article
- Ring stage classification of Babesia microti and Plasmodium falciparum using optical diffraction 3D tomographic technique.Parasites & vectors · 2022Article
- Cyclic Mechanical Stresses Alter Erythrocyte Membrane Composition and Microstructure and Trigger Macrophage Phagocytosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Morphological Characteristics, Hemoglobin Content, and Membrane Mechanical Properties of Red Blood Cell Delivery Systems.ACS applied materials & interfaces · 2022Article
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- 4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation.Nature communications · 2021Article
- Effects of osmolality and solutes on the morphology of red blood cells according to three-dimensional refractive index tomography.PloS one · 2021Article
- Holotomography: Refractive Index as an Intrinsic Imaging Contrast for 3-D Label-Free Live Cell Imaging.Advances in experimental medicine and biology · 2021Article
- Automatic detection and characterization of quantitative phase images of thalassemic red blood cells using a mask region-based convolutional neural network.Journal of biomedical optics · 2020Article
- Non-uniform distribution of myosin-mediated forces governs red blood cell membrane curvature through tension modulation.PLoS computational biology · 2020Article
- Transition to 37°C reveals importance of NADPH in mitigating oxidative stress in stored RBCs.JCI insight · 2019Article
- Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows.Micromachines · 2019Article
- Machine Learning with Optical Phase Signatures for Phenotypic Profiling of Cell Lines.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- Integration of diffraction phase microscopy and Raman imaging for label-free morpho-molecular assessment of live cells.Journal of biophotonics · 2019Article
- Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning.Analytical chemistry · 2019Article
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7 authors.
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Abstract
The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusions. To systematically investigate changes in stored whole blood, the hematological properties of individual RBCs were quantified in blood samples stored for various periods with and without a preservation solution called citrate phosphate dextrose adenine-1 (CPDA-1). With 3-D quantitative phase imaging techniques, the optical measurements for 3-D refractive index (RI) distributions and membrane fluctuations were done at the individual cell level. From the optical measurements, the morphological (volume, surface area and sphericity), biochemical (hemoglobin content and concentration), and mechanical parameters (dynamic membrane fluctuation) were simultaneously quantified to investigate the functionalities and progressive alterations of stored RBCs. Our results show that stored RBCs without CPDA-1 had a dramatic morphological transformation from discocytes to spherocytes within two weeks which was accompanied by significant decreases in cell deformability and cell surface area, and increases in sphericity. However, the stored RBCs with CPDA-1 maintained their morphology and deformability for up to 6 weeks.
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