ArticleScientific reports2016
Evolutionary Dynamics and Complicated Genetic Transmission Network Patterns of HIV-1 CRF01_AE among MSM in Shanghai, China.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 49 citations in OpenAlex.
- Transmitted and pretreatment drug resistance among 69 HIV-1 CRFs in China: the first systematic analysis.Emerging microbes & infections · 2026Article
- A transmission relationship investigation of HIV infection through male-to-male sex among a case of left-behind children with heterosexual orientation in Zhejiang Province of China.Frontiers in public health · 2026Article
- Impact of V179D/E mutations on antiretroviral therapy outcomes in people living with HIV-1: a 3-year retrospective study.Frontiers in cellular and infection microbiology · 2025Article
- Analysis of genotype resistance and HIV-1 transmission risk in HIV-1-infected men who have sex with men in Guiyang, China.Immunity, inflammation and disease · 2024Article
- Transmitted drug resistance and molecular transmission network among treatment-naive HIV-1 patients in Wenzhou, China, 2020-2023.Virology journal · 2024Article
- Transmission network of Hepatitis C virus subtype 2a in Huazhou County, Shaanxi Province, China.BMC infectious diseases · 2024Article
- The origin, dissemination, and molecular networks of HIV-1 CRF65_cpx strain in Hainan Island, China.BMC infectious diseases · 2024Article
- Molecular network characteristics and drug resistance analysis of 392 newly reported MSM HIV/AIDS cases in Chongqing, China.Frontiers in public health · 2024Article
- HIV-1 molecular transmission network and drug resistance in Chongqing, China, among men who have sex with men (2018-2021).Virology journal · 2023Article
- Efficacy of Efavirenz-Based Regimen in Antiretroviral-Naïve Patients with HIV-1 V179D/E Mutations in Shanghai, China.Infectious diseases and therapy · 2023Article
- Transmission networks of hepatitis C virus among HIV/HCV-coinfected patients in Guangdong, China.Virology journal · 2022Article
- Exploring the Evolutionary History and Phylodynamics of Human Immunodeficiency Virus Type 1 Outbreak From Unnao, India Using Phylogenetic Approach.Frontiers in microbiology · 2022Article
- Prevalence of transmitted HIV-1 drug resistance among treatment-naive individuals in China, 2000-2016.Archives of virology · 2021Article
- Analysis of the Driving Factors of Active and Rapid Growth Clusters Among CRF07_BC-Infected Patients in a Developed Area in Eastern China.Open forum infectious diseases · 2021Article
- HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.BMC infectious diseases · 2021Article
- Molecular Epidemiological Analysis of the Origin and Transmission Dynamics of the HIV-1 CRF01_AE Sub-Epidemic in Bulgaria.Viruses · 2021Article
- Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China.Scientific reports · 2021Article
- Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China.Frontiers in genetics · 2021Article
- Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains.BMC infectious diseases · 2020Article
- Molecular network-based intervention brings us closer to ending the HIV pandemic.Frontiers of medicine · 2020Review
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Authors and funding
15 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
To explore the evolutionary dynamics and molecular transmission patterns of HIV-1 CRF01_AE in depth among men who have sex with men (MSM) in Shanghai, we constructed phylogenetic tree and genetic transmission networks based on 1, 152 pol sequences from MSM, 282 from other risk groups and 795 references. Phylogenetic analyses identified two distinct major CRF01_AE lineages and a Shanghai-based sub-lineage. The estimated tMRCAs for lineage 1 and 2 were 1996.0 (1992.9-1999.2) and 1997.8 (1994.3-2001.4), respectively. Of the 1, 152 MSM, 681 (59.1%) were identified as belonging to 241 separate networks. Of these 681 individuals in networks, 74.2% were linked to cases diagnosed in different years, 4.3% were linked to heterosexual women, and 0.7% were linked to persons who inject drugs. A total of 71 networks including 180 individuals diagnosed in Shanghai with the same domicile were found. Recent infection (P = 0.022) and sampling year after 2011 (P < 0.001) were significantly associated with potential transmission links among the networks. Besides, a significant transmission of viruses with drug resistant mutations at V179D/E were found in the networks. Given these findings, we propose that genetic transmission analysis is a useful tool in HIV intervention strategies to curb the spread of virus and promoting public health.
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