ArticleScientific reports2016
A crucial role for spatial distribution in bacterial quorum sensing.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- PEG-Based Living Hydrogels Engineered for Tunable Production of Bioactive Lipopeptides.ACS applied polymer materials · 2026Article
- Spore-Forming Probiotic-Embedded Biomaterials for Targeted Gut Microplastic Biodegradation.ACS pharmacology & translational science · 2026Review
- Phytochemical Quorum-Sensing Inhibitors Against Bacterial Pathogens: Mechanisms of Action and Translational Challenges.Current issues in molecular biology · 2026Review
- Diffusible Signal Factors andBiology · 2025Review
- From single cells to communities: Mathematical perspectives on bacterial quorum sensing.Computational and structural biotechnology journal · 2025Review
- Targeting quorum sensing for manipulation of commensal microbiota.BMC biotechnology · 2024Review
- A 'rich-get-richer' mechanism drives patchy dynamics and resistance evolution in antibiotic-treated bacteria.Molecular systems biology · 2024Article
- Simulation and Modeling of the Adhesion ofPathogens (Basel, Switzerland) · 2024Article
- Microencapsulation and sonication: A multiple physical approach to attenuate the probioticHeliyon · 2023Article
- Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health.Microorganisms · 2023Review
- ImmobilizedMolecules (Basel, Switzerland) · 2022Article
- Characterizing chemical signaling between engineered "microbial sentinels" in porous microplates.Molecular systems biology · 2022Article
- Impact of Quorum Sensing and Tropodithietic Acid Production on the Exometabolome ofFrontiers in microbiology · 2022Article
- Controlled spatial organization of bacterial growth reveals key role of cell filamentation preceding Xylella fastidiosa biofilm formation.NPJ biofilms and microbiomes · 2021Article
- Review
- Microbial competition reduces metabolic interaction distances to the low µm-range.The ISME journal · 2021Article
- Home, sweet home: how mucus accommodates our microbiota.The FEBS journal · 2021Review
- The COM-Poisson Process for Stochastic Modeling of Osmotic Inactivation Dynamics ofFrontiers in microbiology · 2021Article
- Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk.Frontiers in microbiology · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS) is a process that enables bacteria to communicate using secreted signaling molecules, and then makes a population of bacteria to regulate gene expression collectively and control behavior on a community-wide scale. Theoretical studies of efficiency sensing have suggested that both mass-transfer performance in the local environment and the spatial distribution of cells are key factors affecting QS. Here, an experimental model based on hydrogel microcapsules with a three-dimensional structure was established to investigate the influence of the spatial distribution of cells on bacterial QS. Vibrio harveyi cells formed different spatial distributions in the microcapsules, i.e., they formed cell aggregates with different structures and sizes. The cell aggregates displayed stronger QS than did unaggregated cells even when equal numbers of cells were present. Large aggregates (LA) of cells, with a size of approximately 25 μm, restricted many more autoinducers (AIs) than did small aggregates (SA), with a size of approximately 10 μm, thus demonstrating that aggregate size significantly affects QS. These findings provide a powerful demonstration of the fact that the spatial distribution of cells plays a crucial role in bacterial QS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.