Evidence map›Paper›PMID 27698358›Full record

Trial reportScientific reports2016

In-vivo Imaging of Magnetic Fields Induced by Transcranial Direct Current Stimulation (tDCS) in Human Brain using MRI.

Mayank V Jog, Robert X Smith, Kay Jann, Walter Dunn, Belen Lafon, Dennis Truong, Allan Wu, Lucas Parra, Marom Bikson, Danny J J Wang

Abstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Magnetic Resonance Current Density Imaging (MR-CDI).Advances in experimental medicine and biology · 2022
    Article
  10. Article
  11. Article
  12. Impact of brain atrophy on tDCS and HD-tDCS current flow: a modeling study in three variants of primary progressive aphasia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Prefrontal Recruitment Mitigates Risk-Taking Behavior in Human Immunodeficiency Virus-Infected Young Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  19. High-Resolution Multi-Scale Computational Model for Non-Invasive Cervical Vagus Nerve Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mayank V JogBioMedical Engineering Inter-Departmental Program (BME-IDP), University of California Los Angeles, Los Angeles, California, United States.
Robert X SmithLaboratory of FMRI Technology (LOFT), Department of Neurology, University of California Los Angeles, Los Angeles, California, United States.
Kay JannLaboratory of FMRI Technology (LOFT), Department of Neurology, University of California Los Angeles, Los Angeles, California, United States.
Walter DunnDepartment of Psychiatry, University of California Los Angeles, Los Angeles, California, United States.
Belen LafonDepartment of Biomedical Engineering, The City College of The City University of New York, New York, United States.
Dennis TruongDepartment of Biomedical Engineering, The City College of The City University of New York, New York, United States.
Allan WuLaboratory of FMRI Technology (LOFT), Department of Neurology, University of California Los Angeles, Los Angeles, California, United States.
Lucas ParraDepartment of Biomedical Engineering, The City College of The City University of New York, New York, United States.
Marom BiksonDepartment of Biomedical Engineering, The City College of The City University of New York, New York, United States.
Danny J J WangLaboratory of FMRI Technology (LOFT), Department of Neurology, University of California Los Angeles, Los Angeles, California, United States.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Pediatric Template of Brain PerfusionR01MH080892 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WANG, DANNY JJ · 2009 to 2013
$3.3M
Targeted Transcranial Electrotherapy to accelerate Stroke Rehabilitation-Exploratory Trial on AphasiaR44NS092144 · NINDS · SOTERIX MEDICAL,INC. · PI DATTA, ABHISHEK, PARRA, LUCAS C · 2015 to 2018
$3.0M
A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)R01EB014922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, DANNY JJ · 2013 to 2016
$1.8M
Arterial Spin Labeled Perfusion MRI in Acute Ischemic StrokeR01NS081077 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, DANNY JJ · 2012 to 2014
$1.3M
CRCNS: Effects of Weak Applied Currents on Memory Consolidation During SleepR01MH092926 · NIMH · CITY COLLEGE OF NEW YORK · PI PARRA, LUCAS C · 2010 to 2014
$618k
NCATS NIH HHS UL1 TR000124NIBIB NIH HHS R01 EB014922NIMH NIH HHS R01 MH080892NIMH NIH HHS R01 MH092926NIMH NIH HHS R01 MH111896NINDS NIH HHS R01 NS081077NINDS NIH HHS R44 NS092144
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation technique that applies mA currents at the scalp to modulate cortical excitability. Here, we present a novel magnetic resonance imaging (MRI) technique, which detects magnetic fields induced by tDCS currents. This technique is based on Ampere's law and exploits the linear relationship between direct current and induced magnetic fields. Following validation on a phantom with a known path of electric current and induced magnetic field, the proposed MRI technique was applied to a human limb (to demonstrate in-vivo feasibility using simple biological tissue) and human heads (to demonstrate feasibility in standard tDCS applications). The results show that the proposed technique detects tDCS induced magnetic fields as small as a nanotesla at millimeter spatial resolution. Through measurements of magnetic fields linearly proportional to the applied tDCS current, our approach opens a new avenue for direct in-vivo visualization of tDCS target engagement.

Indexed as

Magnetic FieldsTranscranial Magnetic StimulationAdultCerebral CortexFemaleHumansMagnetic Resonance ImagingMale

Identifiers

PMID27698358
PMCPMC5048181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.