ArticleNature materials2017
Complete prevention of blood loss with self-sealing haemostatic needles.
Article in Nature materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 265 citations in OpenAlex.
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- Injectable Deep Eutectic Solvent-Based Ionic Gel With Rapid Gelation and Broad Hemostatic Functionality.Advanced healthcare materials · 2026Article
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- One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis.Materials today. Bio · 2025Article
- Catechol redox maintenance in mussel adhesion.Nature reviews. Chemistry · 2025Review
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- Preparation strategies of mussel-inspired chitosan-based biomaterials for hemostasis.Frontiers in pharmacology · 2024Review
- Recent Development and Applications of Polydopamine in Tissue Repair and Regeneration Biomaterials.International journal of nanomedicine · 2024Review
- Coupling of Adhesion and Anti-Freezing Properties in Hydrogel Electrolytes for Low-Temperature Aqueous-Based Hybrid Capacitors.Nano-micro letters · 2023Article
- Chitosan-Based Hydrogels for Bioelectronic Sensing: Recent Advances and Applications in Biomedicine and Food Safety.Biosensors · 2023Review
- Design of biopolymer-based hemostatic material: Starting from molecular structures and forms.Materials today. Bio · 2022Review
- Article
- Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture.Bioactive materials · 2022Article
- An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis.Nature communications · 2022Article
- Effect of Bio-Inspired Polymer Types on Engineering Characteristics of Cement Composites.Polymers · 2022Article
- Application of Alginate-Based Hydrogels in Hemostasis.Gels (Basel, Switzerland) · 2022Review
- Exploiting Molecular Dynamics in Composite Coatings to Design Robust Super-Repellent Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity.Nature communications · 2022Article
- Engineering a naturally derived hemostatic sealant for sealing internal organs.Materials today. Bio · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bleeding is largely unavoidable following syringe needle puncture of biological tissues and, while inconvenient, this typically causes little or no harm in healthy individuals. However, there are certain circumstances where syringe injections can have more significant side effects, such as uncontrolled bleeding in those with haemophilia, coagulopathy, or the transmission of infectious diseases through contaminated blood. Herein, we present a haemostatic hypodermic needle able to prevent bleeding following tissue puncture. The surface of the needle is coated with partially crosslinked catechol-functionalized chitosan that undergoes a solid-to-gel phase transition in situ to seal punctured tissues. Testing the capabilities of these haemostatic needles, we report complete prevention of blood loss following intravenous and intramuscular injections in animal models, and 100% survival in haemophiliac mice following syringe puncture of the jugular vein. Such self-sealing haemostatic needles and adhesive coatings may therefore help to prevent complications associated with bleeding in more clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.