ReviewThe Journal of international medical research2016
High-flow nasal cannula therapy for adult patients.
Review in The Journal of international medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05075668 (Continuous Positive Airway Pressure Therapy Via Conventional CPAP Face Mask Versus High Flow Nasal Cannula in OSA Patients on the First Postoperative Night- a Pilot Randomised Study), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continuous Positive Airway Pressure Therapy Via Conventional CPAP Face Mask Versus High Flow Nasal Cannula in OSA Patients on the First Postoperative Night- a Pilot Randomised Study
Who cites it
14 citing papers in PubMed.
- High-flow nasal cannula improves clinical efficacy of airway management in patients undergoing awake craniotomy.BMC anesthesiology · 2020Trial
- High-flow nasal oxygen reduces endotracheal intubation: a randomized clinical trial.Therapeutic advances in respiratory diseaseTrial
- High-flow nasal cannulaERJ open research · 2026Article
- Physical and Physiological Mechanisms of Emergent Hydrodynamic Pressure in High-Flow Nasal Cannula Therapy.Advances in respiratory medicine · 2025Review
- High-flow Oxygen and Nitric Oxide inhalation versus high-flow oxygen alone to prevent intubation in hypoxaemic Respiratory failure (HONOR): a pilot randomised controlled trial protocol.Pilot and feasibility studies · 2025Article
- High-Flow Nasal Oxygen Therapy in Preventing Post-Extubation Hypoxaemia and Postoperative Pulmonary Complications: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- High-flow nasal cannula oxygen therapy: physiological basis and clinical applications in anesthesia.Frontiers in medicine · 2025Review
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- Article
- Effect of trans-nasal humidified rapid insufflation ventilatory exchange on reflux and microaspiration in patients undergoing laparoscopic cholecystectomy during induction of general anesthesia: a randomized controlled trial.Frontiers in medicine · 2023Article
- Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen.ERJ open research · 2022Article
- Effect of High-Flow Nasal Cannula for Hypoxemia Following Sun's Procedure in Acute Aortic Dissection Type a Patients.Frontiers in surgery · 2021Article
- Aerosol Delivery to a Critically Ill Patient: A Big Issue Easily Solved by Developing Guidelines.Pulmonary therapy · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-flow nasal cannula (HFNC) oxygen therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. Recently, the use of HFNC in treating adult critical illness patients has significantly increased, and it is now being used in many patients with a range of different disease conditions. However, there are no established guidelines to direct the safe and effective use of HFNC for these patients. This review article summarizes the available published literature on the positive physiological effects, mechanisms of action, and the clinical applications of HFNC, compared with traditional oxygen therapy devices. The available literature suggests that HFNC oxygen therapy is an effective modality for the early treatment of critically adult patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.