ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2016
Improved insights into protein thermal stability: from the molecular to the structurome scale.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of the activity, stability, and mutational characteristics of temperature-adapted enzymes.Bioscience reports · 2021Pooled it
- A generalizable method for the purification and biophysical characterization of bacterial membrane receptors.Protein science : a publication of the Protein Society · 2026Article
- Molecular mechanisms of function deficiencies in KCNQ1 variants associated with Jervell and Lange-Nielsen syndrome.Channels (Austin, Tex.) · 2025Article
- Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Improving Catalytic Efficiency of L-Arabinose Isomerase fromFoods (Basel, Switzerland) · 2024Article
- Homologous Pairs of Low and High Temperature Originating Proteins Spanning the Known Prokaryotic Universe.Scientific data · 2023Article
- Macrocyclic Ionic Liquids with Amino Acid Residues: Synthesis and Influence of Thiacalix[4]arene Conformation on Thermal Stability.Molecules (Basel, Switzerland) · 2022Article
- Pathogenic missense protein variants affect different functional pathways and proteomic features than healthy population variants.PLoS biology · 2021Article
- Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.Science advances · 2021Article
- High-throughput quantification of protein structural change reveals potential mechanisms of temperature adaptation in Mytilus mussels.BMC evolutionary biology · 2020Article
- A comprehensive computational study of amino acid interactions in membrane proteins.Scientific reports · 2019Article
- Insights on protein thermal stability: a graph representation of molecular interactions.Bioinformatics (Oxford, England) · 2019Article
- Bridging the gaps at the physics-chemistry-biology interface.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
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2 authors.
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Abstract
Despite the intense efforts of the last decades to understand the thermal stability of proteins, the mechanisms responsible for its modulation still remain debated. In this investigation, we tackle this issue by showing how a multiscale perspective can yield new insights. With the help of temperature-dependent statistical potentials, we analysed some amino acid interactions at the molecular level, which are suggested to be relevant for the enhancement of thermal resistance. We then investigated the thermal stability at the protein level by quantifying its modification upon amino acid substitutions. Finally, a large scale analysis of protein stability-at the structurome level-contributed to the clarification of the relation between stability and natural evolution, thereby showing that the mutational profile of proteins differs according to their thermal properties. Some considerations on how the multiscale approach could help in unravelling the protein stability mechanisms are briefly discussed.This article is part of the themed issue 'Multiscale modelling at the physics-chemistry-biology interface'.
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