Evidence map›Paper›PMID 27697780›Full record

ReviewCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2017

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

Christopher I Amos, Joe Dennis, Zhaoming Wang, Jinyoung Byun, Fredrick R Schumacher, Simon A Gayther, Graham Casey, David J Hunter, Thomas A Sellers, Stephen B Gruber and 83 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 16 pooled it
33.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 16 syntheses or guidelines pooled it, 386 citations in OpenAlex.

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  8. The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
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  20. Using Polygenic Risk Scores to Refine Risk and Outcomes in High-grade Serous Ovarian Cancer in Australia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article

179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

93 authors at 1 institution in 1 country.

Christopher I AmosBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Christopher.I.Amos@dartmouth.edu.
Joe DennisCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Jinyoung ByunBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Fredrick R SchumacherDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Simon A GaytherThe Center for Bioinformatics and Functional Genomics at Cedars Sinai Medical Center, Greater Los Angeles Area, Los Angeles, California.
Graham CaseyDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
David J HunterDepartment of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Thomas A SellersDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Stephen B GruberDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Alison M DunningCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Laura FachalCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Kimberly DohenyCenter for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Amanda B SpurdleMolecular Cancer Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Yafang LiBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Xiangjun XiaoBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Jane RommCenter for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Elizabeth PughCenter for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Gerhard A CoetzeeVan Andel Research Institute, Grand Rapids, Michigan.
Dennis J HazelettCedars-Sinai Medical Center, Los Angeles, California.
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Charlisse Caga-AnanDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
Christopher A HaimanThe Center for Bioinformatics and Functional Genomics at Cedars Sinai Medical Center, Greater Los Angeles Area, Los Angeles, California.
Ahsan KamalBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Craig LuccariniCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Daniel TessierGénome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada.
Daniel VincentGénome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada.
François BacotGénome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada.
David J Van Den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Stefanie NelsonDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
Stephen DemetriadesUniversity Health Network- The Princess Margaret Cancer Centre, Toronto, California.
David E GoldgarHuntsman Cancer Institute, Salt Lake City, Utah.
Fergus J CouchMayo Clinic, Rochester, Minnesota.
Judith L FormanBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
David V ContiDivision of Biostatistics, Department of Preventive Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University, Göttingen, Germany.
Angela RischUniversity of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Irene Brüske-HohlfeldHelmholtz Zentrum München, Institut für Epidemiologie I, Neuherberg, Oberschleissheim, Germany.
Belynda D HicksCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Hua LingCenter for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Lesley McGuffogCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Andrew LeeCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Karoline KuchenbaeckerCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Penny SoucyCancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada.
Judith ManzResearch Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Julie M CunninghamMayo Clinic, Rochester, Minnesota.
Katja ButterbachCancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Zsofia Kote-JaraiInstitute of Cancer Research, London, England.
Peter KraftDepartment of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Liesel FitzGeraldCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Sara LindströmDepartment of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Marcia AdamsCenter for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
James D McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Catherine M PhelanDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Sara BenllochCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Linda E KelemenDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
Paul BrennanInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Marjorie RigganDepartment of Gynecology, Duke University Medical Center, Durham, North Carolina.
Tracy A O'MaraCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, P.R. China.
Yongyong ShiKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, P.R. China.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Marc T GoodmanCedars-Sinai Medical Center, Los Angeles, California.
Sune F NielsenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Andrew BerchuckDepartment of Gynecology, Duke University Medical Center, Durham, North Carolina.
Sylvie LaboissiereGénome Québec Innovation Centre, Montreal, Canada and McGill University, Montreal, Canada.
Stephanie L SchmitDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Tameka ShelfordCenter for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Christopher K EdlundDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Jack A TaylorMolecular and Genetic Epidemiology Group, National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina.
John K FieldInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Sue K ParkCollege of Medicine, Seoul National University, Gwanak-gu, Seoul, Korea.
Kenneth OffitClinical Genetics Service, Memorial Hospital, New York, New York.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Rita SchmutzlerZentrum Familiärer Brust- und Eierstockkrebs, Universitätsklinikum Köln, Köln, Germany.
Laura OttiniDepartment of Molecular Medicine, Sapienza, University of Rome, Rome, Italy.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Jonathan MarchiniDepartment of Statistics, Oxford University, Oxford, United Kingdom.
Ali Amin Al OlamaCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Rosalind A EelesInstitute of Cancer Research, London, England.
Michael F SeldinDepartment of Biochemistry and Molecular Medicine, University of California at Davis, Davis, California.
Elizabeth GillandersDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
Daniela SeminaraDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Jacques SimardCancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Canada.
Douglas F EastonCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Van Andel Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9M
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
Environmental Exposure and DNA DamageZIAES049032 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$13.4M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Colon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3M
Transdisciplinary Studies of Genetic Variation in Colorectal CancerU19CA148107 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRUBER, STEPHEN B · 2010 to 2014
$11.1M
Transdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 11174Cancer Research UK 15007Cancer Research UK 16561Cancer Research UK 16565Cancer Research UK 17528Cancer Research UK 20861Cancer Research UK 23382NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA138313NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA133996NCI NIH HHS R01 CA136924NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA190182NCI NIH HHS R01 CA192393NCI NIH HHS R25 CA134286NCI NIH HHS U01 CA196386NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148107NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA167551NIGMS NIH HHS P20 GM103534NIH HHS S10 OD020069NLM NIH HHS T32 LM012204World Health Organization 001
6 · The paper itself

Abstract

backgroundCommon cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits.

methodsThe OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers, and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background.

resultsThe OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis.

conclusionsResults from these analyses will enable researchers to identify new susceptibility loci, perform fine-mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental, and lifestyle-related exposures. IMPACT: Ongoing analyses will shed light on etiology and risk assessment for many types of cancer. Cancer Epidemiol Biomarkers Prev; 26(1); 126-35. ©2016 AACR.

Indexed as

FemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenotypeHumansMaleNeoplasmsPolymorphism, Single NucleotidePrevalencePrognosisRisk AssessmentSelection, Genetic

Identifiers

PMID27697780
PMCPMC5224974
OpenAlexW2528850048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.