Evidence map›Paper›PMID 27697746›Full record

SynthesisClinical psychology review2016

Atypical reactivity of heart rate variability to stress and depression across development: Systematic review of the literature and directions for future research.

Jessica L Hamilton, Lauren B Alloy

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical psychology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 6 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 6 syntheses or guidelines pooled it, 169 citations in OpenAlex.

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  20. Autonomic Readiness for Social Threats in Patients with Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jessica L HamiltonTemple University, Department of Psychology, 1701 N. 13th St., Philadelphia, PA 19122, United States. Electronic address: Jessica.leigh.hamilton@temple.edu.
Lauren B AlloyTemple University, Department of Psychology, 1701 N. 13th St., Philadelphia, PA 19122, United States.
Temple University · US

Funding

Risk for Adolescent Depression: Stress, Cognitive Vulnerability, & InflammationR01MH101168 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2013 to 2017
$3.2M
Physiological Markers of Stress Generation and Affect Reactivity in DepressionF31MH106184 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI HAMILTON, JESSICA LEIGH · 2014 to 2015
$64k
NIMH NIH HHS F31 MH106184NIMH NIH HHS R01 MH101168
6 · The paper itself

Abstract

Heart rate variability has received growing attention in the depression literature, with several recent meta-analyses indicating that lower resting heart rate variability is associated with depression. However, the role of fluctuations in heart rate variability (or reactivity) in response to stress in depression remains less clear. The present review provides a systematic examination of the literature on heart rate variability reactivity to a laboratory-induced stressor task and depression, including 26 studies of reactivity in heart rate variability and clinical depression, remitted (or history of) depression, and subthreshold depression (or symptom-level depression) among adults, adolescents, and children. In addition to reviewing the findings of these studies, methodological considerations and conceptual gaps in the literature are addressed. We conclude by highlighting the importance of investigating the potential transactional relationship between heart rate variability reactivity and depression and possible mechanisms underlying this relationship.

Indexed as

AdolescentAdultAgingChildDepressive DisorderHeart RateHumansStress, PsychologicalDepressionHeart rate variabilityReactivityRespiratory sinus arrhythmiaStress

Identifiers

PMID27697746
PMCPMC5233715
OpenAlexW2521323086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.