Evidence map›Paper›PMID 27697548›Full record

ArticleExperimental eye research2016

Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1

Marie A Shatos, Robin R Hodges, Masahiro Morinaga, David E McNay, Rakibul Islam, Sumit Bhattacharya, Dayu Li, Bruce Turpie, Helen P Makarenkova, Sharmila Masli and 2 more

Abstract read
In one paragraph

Article in Experimental eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Emerging functions of thrombospondin-1 in immunity.Seminars in cell & developmental biology · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Marie A ShatosSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
Robin R HodgesSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
Masahiro MorinagaSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
David E McNaySchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
Rakibul IslamSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
Sumit BhattacharyaSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
Dayu LiSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States.
Bruce TurpieDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA, United States.
Helen P MakarenkovaDepartment of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA, United States.
Sharmila MasliDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA, United States.
Tor P UtheimDepartment of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Darlene A DarttSchepens Eye Research Institute/Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, United States. Electronic address: darlene_dartt@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USBoston University · USOslo University Hospital · NOScripps Research Institute · US

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
MECHANISM OF LACRIMAL GLAND SECRETIONR01EY006177 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A · 1985 to 2012
$5.7M
Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
Molecular Mechanisms Underlying Immune Regulation of Ocular InflammationR01EY015472 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI MASLI, SHARMILA · 2004 to 2013
$4.3M
Lacrimal Gland Regeneration:Identification and Isolation of Progenitor CellsR21EY020992 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI DARTT, DARLENE A · 2010 to 2010
$266k
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY006177NEI NIH HHS R01 EY015472NEI NIH HHS R01 EY026202NEI NIH HHS R21 EY020992
6 · The paper itself

Abstract

The purpose of this study was to investigate the changes that occur in the lacrimal glands (LGs) in female thrombospondin 1 knockout (TSP1

Indexed as

Gene Expression RegulationAnimalsBlotting, WesternCytokinesDisease Models, AnimalDNADry Eye SyndromesFemaleImmunohistochemistryLacrimal ApparatusMiceMice, Inbred C57BLReal-Time Polymerase Chain ReactionStem CellsTearsThrombospondin 1CytokinesDNAThrombospondin 1Transcription FactorsCytokinesLacrimal glandMyoepithelial cellsProgenitor cellsSjogrens syndrome

Identifiers

PMID27697548
PMCPMC5121046
OpenAlexW2527836860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.