ArticleThe Journal of allergy and clinical immunology2017
Abnormal B-cell maturation in the bone marrow of patients with germline mutations in PIK3CD.
Abstract readLetter
In one paragraph
Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Genetic Etiologies and Outcomes in Malignancy and Mortality in Activated Phosphoinositide 3-Kinase Delta Syndrome: A Systematic Review.Advances in therapy · 2025Pooled it
- Systematic review of mortality and survival rates for APDS.Clinical and experimental medicine · 2024Pooled it
- Clinical, Immunological, and Genetic Features in Patients with Activated PI3Kδ Syndrome (APDS): a Systematic Review.Clinical reviews in allergy & immunology · 2020Pooled it
- Epitranscriptomic signatures of m5C, m6A, and pseudouridine in COVID-19 reveal host RNA modifications involved in viral pathogenesis.Microbiology spectrum · 2026Article
- E1021K mutation in PIK3CD gene: clinical heterogeneity and therapeutic implications in three pediatric APDS cases.Open life sciences · 2026Article
- Overall survival among patients with activated phosphoinositide 3-kinase delta syndrome (APDS).Orphanet journal of rare diseases · 2025Article
- Curation of gene-disease relationships in primary antibody deficiencies using the ClinGen validation framework.The Journal of allergy and clinical immunology · 2025Article
- EBV-positive diffuse large B cell lymphoma secondary to activated phosphoinositide 3 kinase δ syndrome type 1 (APDS1): a case report and literature review.Frontiers in immunology · 2025Review
- B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study.Immunogenetics · 2024Article
- Phenotypic and Immunological Characterization of Patients with Activated PI3Kδ Syndrome 1 Presenting with Autoimmunity.Journal of clinical immunology · 2024Article
- Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Activated phosphoinositide 3-kinase δ syndrome caused by PIK3CD mutations: expanding the phenotype.Pediatric rheumatology online journal · 2024Article
- Hyperactivation of the PI3K pathway in inborn errors of immunity: current understanding and therapeutic perspectives.Immunotherapy advances · 2024Review
- Modulating the PI3K Signalling Pathway in Activated PI3K Delta Syndrome: a Clinical Perspective.Journal of clinical immunology · 2023Review
- Rescuing the cytolytic function of APDS1 patient T cells via TALEN-mediated PIK3CD gene correction.Molecular therapy. Methods & clinical development · 2023Article
- Inborn errors of human B cell development, differentiation, and function.The Journal of experimental medicine · 2023Review
- Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2.The Journal of experimental medicine · 2023Article
- ANCA vasculitis expands the spectrum of autoimmune manifestations of activated PI3 kinase δ syndrome.Frontiers in pediatrics · 2023Review
- Role of inhibitory signaling in peripheral B cell tolerance.Immunological reviews · 2022Review
- Monogenic susceptibility to live viral vaccines.Current opinion in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Alina E Dulau FloreaDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Md.
Raul C BraylanDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Md.
Kristian T SchafernakDepartment of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill; Division of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, Ariz.
Kelli W WilliamsLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Janine DaubLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Rakesh K GoyalPediatric Hematology/Oncology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pa.
Jennifer M PuckDepartment of Pediatrics, University of California San Francisco, San Francisco, Calif.
V Koneti RaoLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Stefania PittalugaLaboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Gulbu UzelLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Katherine R CalvoDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Md. Electronic address: calvok@mail.nih.gov.
National Institutes of Health · USNational Institutes of Health Clinical Center · USNational Institute of Allergy and Infectious Diseases · USChildren's Hospital of Pittsburgh · USLurie Children's Hospital · USUniversity of California, San Francisco · US
Funding
Clinical, Immunological and Genetic Analyses of ALPS and Related Immunedysregulatory DisordersZIAAI000732 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RAO, V KONETI · 2009 to 2025
$10.5MDETERMINATION OF GPI-ANCHORED PROTEIN EXPRESSION IN BONE MARROWS OF NORMAL INDIVIDUALS AND PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)ZIACL080022 · CLC · CLINICAL CENTER · PI BRAYLAN, RAUL · 2017 to 2019
$0kThe Role of microRNA in Hematologic MalignanciesZIACL090025 · CLC · CLINICAL CENTER · PI CALVO, KATHERINE · 2010 to 2025
$0kIntramural NIH HHS Z99 CL999999Intramural NIH HHS ZIA CL090025
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdolescentB-LymphocytesBone Marrow CellsCell DifferentiationChildChild, PreschoolClass I Phosphatidylinositol 3-KinasesFemaleGerm-Line MutationHematologic DiseasesHumansMalePrecursor Cells, B-LymphoidYoung AdultClass I Phosphatidylinositol 3-KinasesPIK3CD protein, human
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What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.