Evidence map›Paper›PMID 27697432›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates.

Thaís Felli Kubiça, Laura Bedin Denardi, Maria Isabel Azevedo, Vanessa Oliveira, Luiz Carlos Severo, Janio Morais Santurio, Sydney Hartz Alves

Open access · goldAbstract read
In one paragraph

Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Future microbiology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Inhibition ofBioengineered · 2022
    Article
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Thaís Felli KubiçaUniversidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, Santa Maria, RS, Brazil; Universidade Regional Integrada do Alto Uruguai e das Missões (URI), Santiago, RS, Brazil.
Laura Bedin DenardiUniversidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, Santa Maria, RS, Brazil.
Maria Isabel AzevedoUniversidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmacologia, Santa Maria, RS, Brazil.
Vanessa OliveiraUniversidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmacologia, Santa Maria, RS, Brazil.
Luiz Carlos SeveroComplexo Hospitalar Santa Casa, Porto Alegre, RS, Brazil.
Janio Morais SanturioUniversidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmacologia, Santa Maria, RS, Brazil; Universidade Federal de Santa Maria (UFSM), Departamento de Microbiologia e Parasitologia, Santa Maria, RS, Brazil.
Sydney Hartz AlvesUniversidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, Santa Maria, RS, Brazil; Universidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmacologia, Santa Maria, RS, Brazil; Universidade Federal de Santa Maria (UFSM), Departamento de Microbiologia e Parasitologia, Santa Maria, RS, Brazil. Electronic address: sydneyalves.ufsm@gmail.com.
Universidade Federal de Santa Maria · BRSanta Casa Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of both fluconazole-susceptible and fluconazole-resistant Trichosporon asahii. For these analyses, we used the broth microdilution method based on the M27-A3 technique and checkerboard microdilution method. Tacrolimus showed no activity against T. asahii strains (minimal inhibitory concentrations, MICs>64.0μgmL

Indexed as

Amphotericin BAntifungal AgentsCalcineurin InhibitorsCaspofunginDrug InteractionsDrug SynergismEchinocandinsFluconazoleHumansItraconazoleLipopeptidesMicrobial Sensitivity TestsTacrolimusTrichosporonAmphotericin BAntifungal AgentsCalcineurin InhibitorsCaspofunginEchinocandinsFluconazoleItraconazoleLipopeptidesTacrolimusFK506ResistanceSusceptibilitySynergism

Identifiers

PMID27697432
PMCPMC9427583
OpenAlexW2524812175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.