ArticlePsychological medicine2017
Longitudinal alterations in motivational salience processing in ultra-high-risk subjects for psychosis.
Article in Psychological medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia.The international journal of neuropsychopharmacology · 2023Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.Translational psychiatry · 2019Trial
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- 20 Years of Aberrant Salience in Psychosis: What Have We Learned?The American journal of psychiatry · 2025Review
- Latent Growth Models of Longitudinal Changes in Functional Connectivity during Early Stage Psychosis.Neuroinformatics · 2025Article
- Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis.Psychological medicine · 2025Article
- The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier.BMC psychiatry · 2024Article
- Aberrant salience in acute versus chronic schizophrenia: Do medication and positive symptoms make a difference?Indian journal of psychiatry · 2024Article
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Behavioral Response to Catecholamine Depletion in Individuals With Schizophrenia and Healthy Volunteers.Schizophrenia bulletin open · 2023Article
- Latent inhibition, aberrant salience, and schizotypy traits in cannabis users.Schizophrenia research. Cognition · 2022Article
- Linking Salience Signaling With Early Adversity and Affective Distress in Individuals at Clinical High Risk for Psychosis: Results From an Event-Related fMRI Study.Schizophrenia bulletin open · 2022Article
- Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States-A Systematic Review of fMRI Studies.Journal of clinical medicine · 2021Review
- Reinforcement learning abnormalities in the attenuated psychosis syndrome and first episode psychosis.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Evidence of reward system dysfunction in youth at clinical high-risk for psychosis from two event-related fMRI paradigms.Schizophrenia research · 2020Article
- Modeling perception and behavior in individuals at clinical high risk for psychosis: Support for the predictive processing framework.Schizophrenia research · 2020Article
- Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.Journal of psychiatry & neuroscience : JPN · 2020Article
- A Peptide Link Between Human Cytomegalovirus Infection, Neuronal Migration, and Psychosis.Frontiers in psychiatry · 2020Article
- Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.Schizophrenia research · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundImpairments in the attribution of salience are thought to be fundamental to the development of psychotic symptoms and the onset of psychotic disorders. The aim of the present study was to explore longitudinal alterations in salience processing in ultra-high-risk subjects for psychosis.
methodA total of 23 ultra-high-risk subjects and 13 healthy controls underwent functional magnetic resonance imaging at two time points (mean interval of 17 months) while performing the Salience Attribution Test to assess neural responses to task-relevant (adaptive salience) and task-irrelevant (aberrant salience) stimulus features.
resultsAt presentation, high-risk subjects were less likely than controls to attribute salience to relevant features, and more likely to attribute salience to irrelevant stimulus features. These behavioural differences were no longer evident at follow-up. When attributing salience to relevant cue features, ultra-high-risk subjects showed less activation than controls in the ventral striatum at both baseline and follow-up. Within the high-risk sample, amelioration of abnormal beliefs over the follow-up period was correlated with an increase in right ventral striatum activation during the attribution of salience to relevant cue features.
conclusionsThese findings confirm that salience processing is perturbed in ultra-high-risk subjects for psychosis, that this is linked to alterations in ventral striatum function, and that clinical outcomes are related to longitudinal changes in ventral striatum function during salience processing.
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