ReviewCancer medicine2016
β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.
Review in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
245 citing papers in PubMed, 628 citations in OpenAlex.
- Smelling Wellness: Associations Between Botanic Garden Scentscapes and Human Health Gains.International journal of environmental research and public health · 2026Trial
- Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study.Medicina (Kaunas, Lithuania) · 2023Trial
- Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorbMolecules (Basel, Switzerland) · 2022Trial
- Impact of Plant Pre-Processing on the Chemical Profile of Psidium guajava L. (Myrtaceae) Essential Oil and Evaluation of Its Bioactive Potential.Chemistry & biodiversity · 2026Article
- Determinants of Antibacterial Activity inInternational journal of molecular sciences · 2026Article
- β-Caryophyllene protects male fertility and testicular function against paclitaxel-induced damage in a murine model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Elicitor-Mediated Enhancement of Secondary-Metabolite Biosynthesis inPlants (Basel, Switzerland) · 2026Review
- Interaction of β-Caryophyllene with a Simplified Membrane Model and Its Growth-Inhibitory Effect AgainstPathogens (Basel, Switzerland) · 2026Article
- Toxicity of Some Natural Products in the Treatment of Rheumatoid Arthritis.Life (Basel, Switzerland) · 2026Review
- Restoring ciprofloxacin efficacy via β-caryophyllene synergy for concurrent infection control and tissue regeneration.World journal of microbiology & biotechnology · 2026Article
- Characteristic Constituents of Maocangzhu and Beicangzhu Revealed Using Electronic Nose, Electronic Tongue, HS-GC-IMS, and UPLC-Orbitrap Technologies.Molecules (Basel, Switzerland) · 2026Article
- Ginseng nonsaponins: New insights into their pharmacological potentials in inflammasome-driven inflammation and immunopathology.Journal of ginseng research · 2026Review
- The Metabolome of theJournal of natural products · 2026Review
- Effect of Distillation Time on the Yield and Chemical Composition of Leaf Essential Oil fromPlants (Basel, Switzerland) · 2026Article
- Bioactivity-Guided Isolation of Stigmasterol fromPharmaceuticals (Basel, Switzerland) · 2026Article
- β-Caryophyllene confers protection against type 2 diabetic osteoporosis by blocking ferroptosis via the AMPK/Nrf2 pathway.Journal of pharmaceutical analysis · 2026Article
- Crosstalk between autophagy and ferroptosis in liver diseases (Review).International journal of molecular medicine · 2026Review
- Chemical Profiling and Biological Activity of Copaiba Oil-Resin Samples and Development of HPLC-DAD Method for the Analysis of β-Caryophyllene.Biomedical chromatography : BMC · 2026Article
- Headspace GC-MS volatiles profiling in leaves of 4 Cymbopogon species and their vapor-phase antibacterial effects.Scientific reports · 2026Article
- A review of phytochemicals targeting bacterial biofilm and quorum sensing pathways: molecular, microbiological, and mechanistic insights.Archives of microbiology · 2026Review
185 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic effects have hardly been investigated in vivo. In addition, both compounds potentiate the classical drug efficacy by augmenting their concentrations inside the cells. The mechanisms underlying the anticancer activities of these sesquiterpenes are poorly described. BCP is a phytocannabinoid with strong affinity to cannabinoid receptor type 2 (CB
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.