ArticleArthritis & rheumatology (Hoboken, N.J.)2017
Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Association between fat mass and obesity-related variant and osteoarthritis risk: Integrated meta-analysis with bioinformatics.Frontiers in medicine · 2022Pooled it
- Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians.Journal of foot and ankle research · 2020Pooled it
- Racial-Ethnic Differences in Osteoarthritis Pain and Disability: A Meta-Analysis.The journal of pain · 2019Pooled it
- Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.PLoS genetics · 2018Pooled it
- Cultural Factors Influencing Osteoarthritis Care in Asian Communities: A Review of the Evidence.Journal of community health · 2018Pooled it
- COLGALT2 Polymorphisms are Associated with Osteoarthritis Risk and Clinical Severity in a Chinese Population.International journal of general medicine · 2026Article
- Osteochondrosis in horses: An overview of genetic and other factors.Equine veterinary journal · 2026Review
- Applying survey weights to ordinal regression models for improved inference in outcome-dependent samples with ordinal outcomes.Statistical methods in medical research · 2024Article
- Epigenetics in Knee Osteoarthritis: A 2020-2023 Update Systematic Review.Life (Basel, Switzerland) · 2024Review
- Influence of Different Evolutive Forces onGenes · 2023Article
- RNA-Seq Reveals the mRNAs, miRNAs, and lncRNAs Expression Profile of Knee Joint Synovial Tissue in Osteoarthritis Patients.Journal of clinical medicine · 2023Article
- Intergenic Interactions ofLife (Basel, Switzerland) · 2023Article
- Genetics of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- Phenotype-Genotype analysis of caucasian patients with high risk of osteoarthritis.Frontiers in genetics · 2022Article
- The effect of common variants in GDF5 gene on the susceptibility to chronic postsurgical pain.Journal of orthopaedic surgery and research · 2021Article
- Correlation of osteoarthritis or rheumatoid arthritis with bone mineral density in adults aged 20-59 years.Journal of orthopaedic surgery and research · 2021Article
- Identifying the hub gene and immune infiltration of osteoarthritis by bioinformatical methods.Clinical rheumatology · 2021Article
- A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population.Clinical rheumatology · 2020Article
- Interleukin 1 receptor antagonist (Annals of the rheumatic diseases · 2020Article
- Longitudinal MRI structural findings observed in accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.Skeletal radiology · 2019Observational
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
objectiveA major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and we performed replication analysis of previously reported OA loci.
methodsWe performed meta-analysis using a 2-stage design. Stage 1 (discovery) consisted of a GWAS meta-analysis of radiographic knee OA carried out in the Osteoarthritis Initiative and the Johnston County Osteoarthritis Project. Knee OA was defined as definite osteophytes and possible joint space narrowing or total joint replacement in one or both knees. Stage 2 (validation) was performed in the Multicenter Osteoarthritis Study and the Genetics of Osteoarthritis study. We genotyped lead meta-analysis variants (P ≤ 1 × 10
resultsLead variants from stage 1, representing 49 unique loci, were analyzed in stage 2; none met genome-wide significance in the combined analysis of stage 1 and stage 2. We validated 1 locus (rs4867568 near LSP1P3) with nominal significance (P < 0.05), which was also our top finding in the combined meta-analysis (odds ratio [OR] 0.84 [95% confidence interval (95% CI) 0.79-0.91], P = 3.02 × 10
conclusionThese findings provide suggestive evidence of a novel knee OA locus and confirm previously reported associations in GDF5, CHST11, and FTO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.