Evidence map›Paper›PMID 27696533›Full record

ArticleSynapse (New York, N.Y.)2017

Low startle magnitude may be a behavioral marker of vulnerability to cocaine addiction.

Marina G Wheeler, Erica Duncan, Michael Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synapse (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marina G WheelerDepartment of Psychology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322.
Erica DuncanMental Health Service Line, Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, Georgia, 30033.
Michael DavisDepartment of Psychology, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLER37MH047840 · NIMH · YALE UNIVERSITY · PI DAVIS, MICHAEL NMN · 1991 to 2010
$3.6M
Training Program in Neurobiology of Drug AbuseT32DA015040 · NIDA · EMORY UNIVERSITY · PI KUHAR, MICHAEL J · 2003 to 2012
$3.6M
Acoustic startle reduction in cocaine dependenceR01DA018294 · NIDA · EMORY UNIVERSITY · PI DUNCAN, ERICA J · 2006 to 2009
$1.3M
Anatomy and Pharmacology of Fear-Potentiated StartleR01MH047840 · NIMH · EMORY UNIVERSITY · PI WALKER, DAVID · 2011 to 2011
$418k
The role of kynurenine pathway activation in Toxoplasma-linked schizophreniaI01CX000974 · VA · VETERANS HEALTH ADMINISTRATION · PI DUNCAN, ERICA J · 2014 to 2016
–
CSRD VA I01 CX000974NCRR NIH HHS P51 RR000165NIDA NIH HHS R01 DA018294NIDA NIH HHS T32 DA015040NIH HHS P51 OD011132NIMH NIH HHS R01 MH047840NIMH NIH HHS R37 MH047840
6 · The paper itself

Abstract

Cocaine addicted men have low startle magnitude persisting during prolonged abstinence. Low startle rats show greater cocaine self-administration than high startle rats. Low startle may be a marker of a vulnerability to heightened cocaine-related behaviors in rats and similarly may be a marker of vulnerability to cocaine addiction in humans.

Indexed as

Reflex, AcousticReflex, StartleAnimalsCocaine-Related DisordersMaleRatsRats, Sprague-Dawleyacoustic startlecocainedopaminenovelty preferenceself-administration

Identifiers

PMID27696533
PMCPMC5166556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.