Evidence map›Paper›PMID 27696470›Full record

ArticleJournal of applied toxicology : JAT2017

Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine.

Timothy R Fennell, Ninell P Mortensen, Sherry R Black, Rodney W Snyder, Keith E Levine, Eric Poitras, James M Harrington, Christopher J Wingard, Nathan A Holland, Wimal Pathmasiri and 1 more

Abstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Bactericidal and Cytotoxic Properties of Silver Nanoparticles.International journal of molecular sciences · 2019
    Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Timothy R FennellDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Ninell P MortensenDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Sherry R BlackDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Rodney W SnyderDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Keith E LevineDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Eric PoitrasDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
James M HarringtonDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Christopher J WingardDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Nathan A HollandDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Wimal PathmasiriDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
Susan C J SumnerDiscovery - Science - Technology, RTI International, Research Triangle Park, NC, 27709, USA.
RTI International · USEast Carolina University · US

Funding

RTI's Regional Comprehensive Metabolomics Resource CenterU24DK097193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUMNER, SUSAN J · 2012 to 2017
$9.8M
Synthesis and Characterization CoreU19ES019525 · NIEHS · RESEARCH TRIANGLE INSTITUTE · PI FENNELL, TIMOTHY RAYMOND · 2010 to 2014
$6.3M
NIDDK NIH HHS U24 DK097193NIEHS NIH HHS U19 ES019525
6 · The paper itself

Abstract

Few investigations have been conducted on the disposition and fate of silver nanoparticles (AgNP) in pregnancy. The distribution of a single dose of polyvinylpyrrolidone (PVP)-stabilized AgNP was investigated in pregnant rats. Two sizes of AgNP, 20 and 110 nm, and silver acetate (AgAc) were used to investigate the role of AgNP diameter and particle dissolution in tissue distribution, internal dose and persistence. Dams were administered AgNP or AgAc intravenously (i.v.) (1 mg kg

Indexed as

AcetatesAdministration, IntravenousAdministration, OralAdultCardiovascular DiseasesCytokinesFemaleFetusHumansMaternal-Fetal ExchangeMetabolomicsMetal NanoparticlesOxidative StressParticle SizePlacentaPregnancyAcetatesCytokinesSilversilver acetateSilver Compoundsbiomarkerscytokinesintravenous injectionin vivo distributionmaternal-fetal transfermetabolomics analysisoral gavageoxidative stresspregnant ratssilver nanoparticles

Identifiers

PMID27696470
PMCPMC5373957
OpenAlexW2527819170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.