Evidence map›Paper›PMID 27696303›Full record

ArticleEndocrine pathology2017

MALAT1 Long Non-coding RNA Expression in Thyroid Tissues: Analysis by In Situ Hybridization and Real-Time PCR.

Ranran Zhang, Heather Hardin, Wei Huang, Jidong Chen, Sofia Asioli, Alberto Righi, Francesca Maletta, Anna Sapino, Ricardo V Lloyd

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

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  17. LncRNAs as Potential Therapeutic Targets in Thyroid Cancer.Asian Pacific journal of cancer prevention : APJCP · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ranran ZhangDepartment of Laboratory Medicine and Pathology K4/436, University of Wisconsin School of Medicine and Public Health, Box 8550, Madison, WI, 53792, USA.
Heather HardinDepartment of Laboratory Medicine and Pathology K4/436, University of Wisconsin School of Medicine and Public Health, Box 8550, Madison, WI, 53792, USA.
Wei HuangDepartment of Laboratory Medicine and Pathology K4/436, University of Wisconsin School of Medicine and Public Health, Box 8550, Madison, WI, 53792, USA.
Jidong ChenDepartment of Laboratory Medicine and Pathology K4/436, University of Wisconsin School of Medicine and Public Health, Box 8550, Madison, WI, 53792, USA.
Sofia AsioliUniversity of Bologna, Bologna, Italy.
Alberto RighiRizzoli Institute, Bologna, Italy.
Francesca MalettaUniversity of Turin, Turin, Italy.
Anna SapinoUniversity of Turin, Turin, Italy.
Ricardo V LloydDepartment of Laboratory Medicine and Pathology K4/436, University of Wisconsin School of Medicine and Public Health, Box 8550, Madison, WI, 53792, USA. rvlloyd@wisc.edu.
University of Wisconsin–Madison · USUniversity of Turin · ITIstituto Ortopedico Rizzoli · ITUniversity of Bologna · IT

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Studies of Normal and Neoplastic Human PituitariesR01CA090249 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI LLOYD, RICARDO VINCENT · 2001 to 2005
$1.2M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA090249
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are important for transcription and for epigenetic or posttranscriptional regulation of gene expression and may contribute to carcinogenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), an lncRNA involved in the regulation of the cell cycle, cell proliferation, and cell migration, is known to be deregulated in multiple cancers. Here, we analyzed the expression of MALAT1 on 195 cases of benign and malignant thyroid neoplasms by using tissue microarrays for RNA in situ hybridization (ISH) and real-time PCR. MALAT1 is highly expressed in normal thyroid (NT) tissues and thyroid tumors, with increased expression during progression from NT to papillary thyroid carcinomas (PTCs) but is downregulated in poorly differentiated thyroid cancers (PDCs) and anaplastic thyroid carcinomas (ATCs) compared to NT. Induction of epithelial to mesenchymal transition (EMT) by transforming growth factor (TGF)-beta in a PTC cell line (TPC1) led to increased MALAT1 expression, supporting a role for MALAT1 in EMT in thyroid tumors. This is the first ISH study of MALAT1 expression in thyroid tissues. It also provides the first piece of evidence suggesting MALAT1 downregulation in certain thyroid malignancies. Our findings support the notion that ATCs may be molecularly distinct from low-grade thyroid malignancies and suggest that MALAT1 may function both as an oncogene and as a tumor suppressor in different types of thyroid tumors.

Indexed as

Epithelial-Mesenchymal TransitionHumansImage Processing, Computer-AssistedIn Situ HybridizationReal-Time Polymerase Chain ReactionRNA, Long NoncodingThyroid GlandThyroid NeoplasmsTissue Array AnalysisMALAT1 long non-coding RNA, humanRNA, Long NoncodingIn situ hybridizationLong non-coding RNAMALAT1Papillary thyroid carcinomaRT-PCRThyroid carcinoma

Identifiers

PMID27696303
PMCPMC5313332
OpenAlexW2524020835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.