Evidence map›Paper›PMID 27696186›Full record

SynthesisJournal of autism and developmental disorders2017

Anxiety Disorders in Williams Syndrome Contrasted with Intellectual Disability and the General Population: A Systematic Review and Meta-Analysis.

R Royston, P Howlin, J Waite, C Oliver

Registry-linked trialOpen access · hybridAbstract readComparative StudyMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03827525 (Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03827525 unknown statusnot on this mapstarted 2019, after this paper: background citation

Cognitive and Behavioral Therapy of Anxiety in Williams Syndrome

TypeobservationalSponsorUniversity Hospital, MontpellierRan2019 to 2021Enrolled5ConditionsWilliams Syndrome, AnxietyArmsCognitive and Behavioral Therapy
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Repetitive Thoughts and Repetitive Behaviors in Williams Syndrome.Journal of autism and developmental disorders · 2022
    Article
  16. Article
  17. Anxiety in Angelman Syndrome.American journal on intellectual and developmental disabilities · 2022
    Article
  18. Autism and Williams syndrome: truly mirror conditions in the socio-cognitive domain?International journal of developmental disabilities · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

R RoystonThe Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. rxr180@bham.ac.uk.ORCID http://orcid.org/0000-0002-9901-2284
P HowlinDepartment of Psychology, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.
J WaiteThe Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
C OliverThe Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
University of Birmingham · GBThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with specific genetic syndromes associated with intellectual disability (ID), such as Williams syndrome (WS), are at increased risk for developing anxiety disorders. A systematic literature review identified sixteen WS papers that could generate pooled prevalence estimates of anxiety disorders for WS. A meta-analysis compared these estimates with prevalence estimates for the heterogeneous ID population and the general population. Estimated rates of anxiety disorders in WS were high. WS individuals were four times more likely to experience anxiety than individuals with ID, and the risk was also heightened compared to the general population. The results provide further evidence of an unusual profile of high anxiety in WS.

Indexed as

Anxiety DisordersChildFemaleHumansIntellectual DisabilityMaleWilliams SyndromeAnxiety disordersGenetic syndromesIntellectual disabilityMeta-analysisSystematic reviewWilliams syndrome

Identifiers

PMID27696186
PMCPMC5676825
OpenAlexW2526396955

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.