ArticleJournal of assisted reproduction and genetics2016
Blastomere biopsy for PGD delays embryo compaction and blastulation: a time-lapse microscopic analysis.
Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Correlation between AMH levels and embryonic aneuploidy rate in PGT-A patients: a retrospective study.Journal of assisted reproduction and genetics · 2025Article
- The outcomes of blastocyst versus cleavage stage embryo biopsy for preimplantation genetic testing for monogenic diseases.Frontiers in endocrinology · 2025Article
- Review
- Preimplantation genetic testing in the current era, a review.Archives of gynecology and obstetrics · 2024Review
- Evolution of Minimally Invasive and Non-Invasive Preimplantation Genetic Testing: An Overview.Journal of clinical medicine · 2024Review
- Artificial intelligence in time-lapse system: advances, applications, and future perspectives in reproductive medicine.Journal of assisted reproduction and genetics · 2024Review
- PGT-A is associated with reduced cumulative live birth rate in first reported IVF stimulation cycles age ≤ 40: an analysis of 133,494 autologous cycles reported to SART CORS.Journal of assisted reproduction and genetics · 2023Article
- An Update on Non-invasive Approaches for Genetic Testing of the Preimplantation Embryo.Current genomics · 2022Review
- Non-Invasive Preimplantation Genetic Testing for Aneuploidy and the Mystery of Genetic Material: A Review Article.International journal of molecular sciences · 2022Review
- New insights regarding origin of monosomy occurrence in early developing embryos as demonstrated in preimplantation genetic testing.Molecular cytogenetics · 2022Article
- Different Strategies of Preimplantation Genetic Testing for Aneuploidies in Women of Advanced Maternal Age: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- Diagnostic efficiency of blastocyst culture medium in noninvasive preimplantation genetic testing.F&S reports · 2021Article
- Good practice recommendations for the use of time-lapse technologyHuman reproduction open · 2020Article
- Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.Journal of assisted reproduction and genetics · 2019Article
- Impact of polar body biopsy on embryo morphokinetics-back to the roots in preimplantation genetic testing?Journal of assisted reproduction and genetics · 2018Article
- High-efficiency derivation of human embryonic stem cell lines using a culture system with minimized trophoblast cell proliferation.Stem cell research & therapy · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of the study was to explore the effect of blastomere biopsy for preimplantation genetic diagnosis (PGD) on the embryos' dynamics, further cleavage, development, and implantation.
methodsThe study group included 366 embryos from all PGD treatments (September 2012 to June 2014) cultured in the EmbryoScope™ time-lapse monitoring system. The control group included all intracytoplasmic sperm injection (ICSI) embryos cultured in EmbryoScope™ until day 5 during the same time period (385 embryos). Time points of key embryonic events were analyzed with an EmbryoViewer™.
resultsMost (88 %) of the embryos were biopsied at ≥8 cells. These results summarize the further dynamic development of the largest cohort of biopsied embryos and demonstrate that blastomere biopsy of cleavage-stage embryos significantly delayed compaction and blastulation compared to the control non-biopsied embryos. This delay in preimplanation developmental events also affected postimplantation development as observed when the dynamics of non-implanted embryos (known implantation data (KID) negative) were compared to those of implanted embryos (KID positive).
conclusionAnalysis of morphokinetic parameters enabled us to explore how blastomere biopsy interferes with the dynamic sequence of developmental events. Our results show that biopsy delays the compaction and the blastulation of the embryos, leading to a decrease in implantation.
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