Evidence map›Paper›PMID 27696085›Full record

ArticlePurinergic signalling2017

Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium.

Kevin J Ashton, Melissa E Reichelt, S Jamal Mustafa, Bunyen Teng, Catherine Ledent, Lea M D Delbridge, Polly A Hofmann, R Ray Morrison, John P Headrick

Open access · greenAbstract read
In one paragraph

Article in Purinergic signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. The Impact ofAnimals : an open access journal from MDPI · 2025
    Article
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  5. Effects of Heat-Induced Oxidative Stress and Astaxanthin on theCurrent issues in molecular biology · 2024
    Article
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  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Role of Cardiac AFrontiers in pharmacology · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Kevin J AshtonFaculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia.
Melissa E ReicheltSchool of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
S Jamal MustafaDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.
Bunyen TengDepartment of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.
Catherine LedentUniversite Libre de Bruxelles, Brussels, Belgium.
Lea M D DelbridgeDepartment of Physiology, University of Melbourne, Parkville, VIC, Australia.
Polly A HofmannDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
R Ray MorrisonDivision of Critical Care Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.
John P HeadrickHeart Foundation Research Center, Griffith University, Southport, QLD, 4217, Australia. j.headrick@griffith.edu.au.
West Virginia University · USBond University · AUNational Heart Foundation of Australia · AUSt. Jude Children's Research Hospital · USUniversité Libre de Bruxelles · BEUniversity of Melbourne · AUUniversity of Queensland · AUUniversity of Tennessee Health Science Center · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
MECHANISMS OF CORONARY FLOW REGULATION BY ADENOSINER01HL027339 · NHLBI · WEST VIRGINIA UNIVERSITY · PI MUSTAFA, S. JAMAL · 1986 to 2015
$5.0M
Mechanisms of Hormonal Regulation of Cardiac ContractionR01HL048839 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HOFMANN, POLLY A · 1998 to 2004
$1.1M
Ischemia-Reperfusion in A2A and A2B Knockout HeartsK08HL074001 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MORRISON, R RAY · 2003 to 2007
$623k
NHLBI NIH HHS K08 HL074001NHLBI NIH HHS R01 HL027339NHLBI NIH HHS R01 HL048839NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Influences of adenosine 2A receptor (A

Indexed as

AnimalsEndotoxemiaGene Expression ProfilingInflammationJanus Kinase 1MiceMice, KnockoutMyocardiumNF-kappa BReceptor, Adenosine A2ASTAT Transcription FactorsTranscriptomeJanus Kinase 1NF-kappa BReceptor, Adenosine A2ASTAT Transcription FactorsAdenosineAdenosine 2A receptorAnti-inflammatoryCytokinesEndotoxemic myocarditisGene expressionInflammationMicroarraySepsis

Identifiers

PMID27696085
PMCPMC5334196
OpenAlexW2527488980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.