ArticleJournal of the Association for Research in Otolaryngology : JARO2017
Tyrosine Hydroxylase Expression in Type II Cochlear Afferents in Mice.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Conditional Deletion of Isl1 Disrupts Cochlear Sensory and Neuronal Development, Leading to Hearing Loss.Molecular neurobiology · 2026Article
- Expression of the P2X1 receptor remains in the type II spiral ganglion neurons in the mature rat cochlea.Purinergic signalling · 2026Article
- Defects in hair cells disrupt the development of auditory peripheral circuitry.Nature communications · 2024Article
- Damage-evoked signals in cochlear neurons and supporting cells.Frontiers in neurology · 2024Review
- Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons.Cellular and molecular neurobiology · 2023Article
- Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.The Journal of physiology · 2023Article
- Axonal mapping of the motor cranial nerves.Frontiers in neuroanatomy · 2023Article
- Specification of neuronal subtypes in the spiral ganglion begins prior to birth in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- Acoustic Trauma Increases Ribbon Number and Size in Outer Hair Cells of the Mouse Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Developmental Changes inFrontiers in cellular neuroscience · 2021Article
- Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart.Journal of anatomy · 2021Article
- Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation.Science advances · 2021Article
- Distribution of KExperimental neurobiology · 2020Article
- Article
- Hair Cell Afferent Synapses: Function and Dysfunction.Cold Spring Harbor perspectives in medicine · 2019Review
- Regulation of Noise-Induced Loss of Serotonin Transporters with Resveratrol in a Rat Model Using 4-[Molecules (Basel, Switzerland) · 2019Article
- Characterization of transgenic mouse lines for labeling type I and type II afferent neurons in the cochlea.Scientific reports · 2019Article
- Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system.Nature communications · 2018Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Acoustic information propagates from the ear to the brain via spiral ganglion neurons that innervate hair cells in the cochlea. These afferents include unmyelinated type II fibers that constitute 5 % of the total, the majority being myelinated type I neurons. Lack of specific genetic markers of type II afferents in the cochlea has been a roadblock in studying their functional role. Unexpectedly, type II afferents were visualized by reporter proteins induced by tyrosine hydroxylase (TH)-driven Cre recombinase. The present study was designed to determine whether TH-driven Cre recombinase (TH-2A-CreER) provides a selective and reliable tool for identification and genetic manipulation of type II rather than type I cochlear afferents. The "TH-2A-CreER neurons" radiated from the spiral lamina, crossed the tunnel of Corti, turned towards the base of the cochlea, and traveled beneath the rows of outer hair cells. Neither the processes nor the somata of TH-2A-CreER neurons were labeled by antibodies that specifically labeled type I afferents and medial efferents. TH-2A-CreER-positive processes partially co-labeled with antibodies to peripherin, a known marker of type II afferents. Individual TH-2A-CreER neurons gave off short branches contacting 7-25 outer hair cells (OHCs). Only a fraction of TH-2A-CreER boutons were associated with CtBP2-immunopositive ribbons. These results show that TH-2A-CreER provides a selective marker for type II versus type I afferents and can be used to describe the morphology and arborization pattern of type II cochlear afferents in the mouse cochlea.
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Registered trials
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