Evidence map›Paper›PMID 27695990›Full record

ArticleEuropean journal of pediatrics2016

Functional and genetic predisposition to rhinovirus lower respiratory tract infections in prematurely born infants.

Simon B Drysdale, Mireia Alcazar, Theresa Wilson, Melvyn Smith, Mark Zuckerman, Hennie M Hodemaekers, Riny Janssen, Louis Bont, Sebastian L Johnston, Anne Greenough

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  3. Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Simon B DrysdaleDivision of Asthma, Allergy and Lung Biology, MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, SE5 9RS, UK.
Mireia AlcazarDivision of Asthma, Allergy and Lung Biology, MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, SE5 9RS, UK.
Theresa WilsonDivision of Asthma, Allergy and Lung Biology, MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, SE5 9RS, UK.
Melvyn SmithSouth London Specialist Virology Centre, King's College Hospital, London, SE5 9RS, UK.
Mark ZuckermanSouth London Specialist Virology Centre, King's College Hospital, London, SE5 9RS, UK.
Hennie M HodemaekersCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Riny JanssenCentre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Louis BontWilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.
Sebastian L JohnstonAirway Disease Infection Section, National Heart and Lung Institute, Imperial College London, W2 1PG, London, UK.
Anne GreenoughDivision of Asthma, Allergy and Lung Biology, MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, SE5 9RS, UK. anne.greenough@kcl.ac.uk.ORCID http://orcid.org/0000-0002-8672-5349
King's College London · GBKing's College Hospital · GBNational Institute for Public Health and the Environment · NLImperial College London · GBWilhelmina Children's Hospital · NL

Funding

Medical Research Council G1000758
6 · The paper itself

Abstract

Term born infants are predisposed to human rhinovirus (HRV) lower respiratory tract infections (LRTI) by reduced neonatal lung function and genetic susceptibility. Our aim was to investigate whether prematurely born infants were similarly predisposed to HRV LRTIs or any other viral LRTIs. Infants born less than 36 weeks of gestational age were recruited. Prior to neonatal/maternity unit discharge, lung function (functional residual capacity by helium gas dilution and multiple breath washout, lung clearance index and compliance (C

conclusionPrematurely born infants may have both a functional and genetic predisposition to HRV LRTIs. What is Known: • Term born infants are predisposed to rhinovirus lower respiratory tract (HRV LRTIs) infection by reduced neonatal lung function. • Term born infants requiring hospitalisation due to HRV bronchiolitis were more likely to have single nucleotide polymorphism (SNP) in the IL-10 gene. What is New: • Prematurely born infants who developed a HRV LRTI had lower C

Indexed as

Genetic Predisposition to DiseaseChild, PreschoolDNAFemaleHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInterleukin-10LungMaleNeonatal ScreeningPolymorphism, Single NucleotideProspective StudiesRespiratory Syncytial Virus InfectionsDNAInterleukin-10Compliance and resistance of the respiratory systemFunctional residual capacityHuman rhinovirusSingle nucleotide polymorphisms

Identifiers

PMID27695990
OpenAlexW2525113132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.