Evidence map›Paper›PMID 27695980›Full record

Trial reportEuropean journal of applied physiology2016

Effects of caffeine ingestion on endurance performance in mentally fatigued individuals.

Rafael Azevedo, Marcos David Silva-Cavalcante, Bruno Gualano, Adriano E Lima-Silva, Romulo Bertuzzi

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06952283 (Effects of Music Intervention on Golf-Specific Skill Performance of Chinese Golfers Under Mental Fatigue), which is not on this map. Cited by 41 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 7 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06952283 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Music Intervention on Golf-Specific Skill Performance of Chinese Golfers Under Mental Fatigue

TypeinterventionalSponsorPan XiaoyangRan2025 to 2025Enrolled60ConditionsMental FatigueArmsInducing mental fatigue, Music intervention
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 7 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  17. The Effect of Ammonia Inhalants on Mental-Fatigue-Related Force Loss.Journal of functional morphology and kinesiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rafael AzevedoEndurance Performance Research Group, Departamento de Esporte, School of Physical Education and Sport (GEDAE-USP), University of São Paulo, Av. Professor Melo de Moraes, 65, Cidade Universitária, São Paulo, SP, 05508-030, Brazil.
Marcos David Silva-CavalcanteEndurance Performance Research Group, Departamento de Esporte, School of Physical Education and Sport (GEDAE-USP), University of São Paulo, Av. Professor Melo de Moraes, 65, Cidade Universitária, São Paulo, SP, 05508-030, Brazil.
Bruno GualanoSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Adriano E Lima-SilvaSports Science Research Group, Academic Center of Vitoria, Federal University of Pernambuco, Recife, Brazil.
Romulo BertuzziEndurance Performance Research Group, Departamento de Esporte, School of Physical Education and Sport (GEDAE-USP), University of São Paulo, Av. Professor Melo de Moraes, 65, Cidade Universitária, São Paulo, SP, 05508-030, Brazil. bertuzzi@usp.br.
Universidade de São Paulo · BRUniversidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the effects of caffeine ingestion on physiological and perceptual responses in mentally fatigued individuals.

methodsEight male physically active subjects completed four cycling constant-workload tests in four experimental conditions at 80 % of maximal power output: control (C), mental fatigue (MF), mental fatigue plus caffeine ingestion (5 mg/kg) (MF-CAF), and mental fatigue plus placebo (MF-PLA). The mental fatigue was induced by a continuous performance task A-X version (AX-CPT). Before and after the AX-CPT, the profile of mood state (POMS) and blood samples for lactate measurement were collected. Oxygen consumption ([Formula: see text]), rating of perceived exertion (RPE), and electromyography (EMG) activity were measured during the cycling test.

resultsThe time to exhaustion in C, MF, MF-PLA, and MF-CAF were 251 ± 30, 222 ± 23, 248 ± 28, and 285 ± 42 s, respectively. Delta values (corrected by C condition) were higher in MF-CAF than MF (P = 0.031). MF-CAF reported higher Vigor scores when compared with C (P = 0.046) and MF (P = 0.020). RPE at the first minute was significantly higher in MF-PLA than in C (P = 0.050); at the second minute, RPE was higher in MF-PLA than in C (P = 0.049) and MF-CAF (P = 0.048). EMG activity was not different between the conditions.

conclusionsCaffeine ingestion increased approximately 14 % endurance performance after the induction of mental fatigue. This effect was accompanied by a tendency to improvement in mood state (i.e., vigor). Therefore, caffeine ingestion can promote a beneficial effect on endurance performance in mentally fatigued individuals.

Indexed as

Administration, OralAffectCaffeineCentral Nervous System StimulantsDose-Response Relationship, DrugHumansMaleMental FatiguePhysical EndurancePhysical ExertionPsychomotor PerformanceTreatment OutcomeYoung AdultCaffeineCentral Nervous System StimulantsCaffeine ingestionEndurance capacityMental fatigueMood state

Identifiers

PMID27695980
OpenAlexW2527604003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.