ArticleEuropean journal of clinical pharmacology2017
Assessing adherence to inhaled corticosteroids in asthma patients using an integrated measure based on primary and secondary adherence.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Suitability of Measures of Pharmacy-Based Medication Adherence for Routine Clinical Use Among Patients with Chronic Diseases: A Systematic Review.Patient preference and adherence · 2025Review
- Estimating medication adherence from Electronic Health Records: comparing methods for mining and processing asthma treatment prescriptions.BMC medical research methodology · 2023Article
- Impact of Unmet Social Needs, Scarcity, and Future Discounting on Adherence to Treatment in Children With Asthma: Protocol for a Prospective Cohort Study.JMIR research protocols · 2023Article
- Pediatric Medication Noninitiation in Spain.Pediatrics · 2022Observational
- Measuring Medication Adherence in a Population-Based Asthma Administrative Pharmacy Database: A Systematic Review and Meta-Analysis.Clinical epidemiology · 2021Review
- Linkage of primary care prescribing records and pharmacy dispensing Records in the Salford Lung Study: application in asthma.BMC medical research methodology · 2020Article
- Global Initiative for Asthma report: How will new recommendations affect practice in Canada?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Efficacy of treatment with montelukast, fluticasone propionate and budesonide liquid suspension for the prevention of recurrent asthma paroxysms in children with wheezing disorders.Experimental and therapeutic medicine · 2019Article
- Challenges and choices in the pharmacological treatment of non-severe pediatric asthma: A commentary for the practicing physician.The World Allergy Organization journal · 2019Article
- Longitudinal Patterns of Mexican and Puerto Rican Children's Asthma Controller Medication Adherence and Acute Healthcare Use.Annals of the American Thoracic Society · 2019Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere are very few studies on primary adherence (i.e., first filling of a prescription) to inhaled corticosteroids (ICS) in asthma patients; two have involved children. Moreover, adherence can be overestimated when considering only secondary adherence (i.e., following the medication recommendations for a defined period) and ignoring primary adherence. We aimed thus to evaluate the real-world primary and secondary adherence to ICS and to develop an integrated primary and secondary adherence (IPSA) measure.
methodsFrom two clinical databases of pediatric and adult asthma patients, we included 198 children and 206 adults with one ICS prescription recorded in their medical chart between 2010 and 2012 and follow-up data for ≥12 months. Adherence was estimated from written prescriptions and prescription claims data. Primary adherence was defined as filling the ICS prescription at a pharmacy within 12 months. Secondary adherence was defined as the proportion of days covered (PDC) in subjects who filled their prescription at least once. The IPSA was based on the PDC with a correction factor for primary adherence.
resultsPrimary adherence to ICS at 12 months was 89.4 % in children and 69.4 % in adults. Secondary adherence at 12 months in children was 33.9 %, and the IPSA was 30.3 %. These values were 52.8 and 36.6 %, respectively, in adults.
conclusionsPrimary adherence to ICS is low in adults and secondary adherence is poor in children and adults. Using the PDC as a unique measure of adherence led to significant overestimation in adults; IPSA leads to more valid estimates of adherence to ICS.
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