Evidence map›Paper›PMID 27695904›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2017

Articular cartilage paste graft for severe osteochondral lesions of the knee: a 10- to 23-year follow-up study.

Kevin R Stone, Jonathan R Pelsis, Kellen Na, Ann W Walgenbach, Thomas J Turek

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Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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7citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kevin R StoneStone Research Foundation, San Francisco, CA, USA. kstonemd@stoneclinic.com.
Jonathan R PelsisStone Research Foundation, San Francisco, CA, USA.
Kellen NaStone Research Foundation, San Francisco, CA, USA.
Ann W WalgenbachStone Research Foundation, San Francisco, CA, USA.
Thomas J TurekStone Research Foundation, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to evaluate the clinical outcomes of the articular cartilage paste graft procedure at a minimum of 10 years from surgery. It is hypothesized that articular cartilage paste grafting can provide patients with a durable repair of severe full-thickness osteochondral injuries, measured by persistence of procedure-induced benefit and subjective outcome scores at 10 or more years.

methodsSeventy-four patients undergoing paste grafting at a mean age of 45.3 ± 10.8 years (range 13-69 years) were followed up at a mean of 16.8 ± 2.4 years (range 10.6-23.2 years) post-operatively using validated subjective outcome measures; Kaplan-Meier survival analysis was performed to estimate expected population benefit time.

resultsKaplan-Meier estimated median benefit time of 19.1 years (mean: 16.6 ± 0.9 years) for all patients undergoing paste grafting. Thirty-one (41.9 %) patients had progressed to arthroplasty at a mean of 9.8 ± 5.6 years (range 0.4-20.6 years). Ninety percent of patients reported that the procedure provided good to excellent pain relief. Median IKDC subjective score increased significantly at most recent follow-up (70.1) compared to preoperative (55.7, p = 0.013). Median WOMAC scores decreased significantly from 26 to 14 (p = 0.001). Median Tegner score increase from 4 to 6 was not found to be significant (ns). VAS pain averaged 23/100 at most recent follow-up.

conclusionsPatients who underwent the paste grafting reported improved pain, function, and activity levels for an expected mean of 16.6 years, and for those who ultimately progressed to knee replacement, surgical treatment including the paste graft was able to delay arthroplasty until a mean age of 60.2 years, an age at which the procedure is commonly performed. Full-thickness articular cartilage loss can be successfully treated, reducing pain, and improving function, using this single-step, inexpensive arthroscopic procedure. LEVEL OF EVIDENCE: IV.

Indexed as

ArthroscopyTransplantsTreatment OutcomeAdolescentAdultAgedCartilageCartilage, ArticularFemaleFollow-Up StudiesHumansIntra-Articular FracturesKnee JointMaleMiddle AgedOsteoarthritisArthroscopyArticular cartilageArticular cartilage repairAutologous cartilage transplantationBiologic knee repairCartilage reconstructionHistologyKneeLong-term clinical outcomeOrthobiologicsOsteoarthritisOsteochondral graftingPaste graftSurvival analysisTreatment gap

Identifiers

PMID27695904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.