Evidence map›Paper›PMID 27695894›Full record

Trial reportIntensive care medicine2016

A recovery program to improve quality of life, sense of coherence and psychological health in ICU survivors: a multicenter randomized controlled trial, the RAPIT study.

Janet F Jensen, Ingrid Egerod, Morten H Bestle, Doris F Christensen, Ask Elklit, Randi L Hansen, Heidi Knudsen, Louise B Grode, Dorthe Overgaard

3 registry-linked trialsAbstract readMulticenter StudyPragmatic Clinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 51 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 9 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01721239 nacompletednot on this map

Recovery and Aftercare in Post Intensive Care Therapy Patients - The RAPIT Study. The Effectiveness and Experiences of a Follow-up Program for Danish Mechanically Ventilated ICU Patients: A Pragmatic Randomized Controlled Multicentre Trial.

TypeinterventionalSponsorHillerod Hospital, DenmarkRan2012 to 2016Enrolled340ConditionsIntensive Care (ICU) PatientsArmsStandardized Followup program
NCT03264365 nacompletednot on this map

The Effectiveness of a Post-ICU Recovery Program on Relatives to Patients Receiving Mechanically Ventilatory Support: Data Linked to RAPIT-I Investigation

TypeinterventionalSponsorHolbaek SygehusRan2012 to 2018Enrolled181ConditionsIntensive Care Unit Syndrome, RelativesArmsIntervention
NCT03915977 completednot on this map

Patterns of PTSD Over Time in Adult Intensive Care Patients - Observations From the RAPIT Trial

Typeobservational_patient_registrySponsorHolbaek SygehusRan2012 to 2015Enrolled386ConditionsIntensive Care Unit SyndromeArmsPost ICU recovery program
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 9 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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  19. ICU Recovery Interventions: Is It Time for a Personalized Medicine Approach?American journal of respiratory and critical care medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Janet F JensenDepartment of Anesthesiology, Nordsjællands Hospital, University of Copenhagen, 3400, Hilleroed, Denmark. janet.froulund.jensen@regionh.dk.
Ingrid EgerodNeurointensive Care Unit, Rigshospitalet, University of Copenhagen and Health & Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Morten H BestleDepartment of Anesthesiology, Nordsjællands Hospital, University of Copenhagen, 3400, Hilleroed, Denmark.
Doris F ChristensenDepartment of Anesthesiology, Nordsjællands Hospital, University of Copenhagen, 3400, Hilleroed, Denmark.
Ask ElklitDepartment of Psychology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
Randi L HansenDepartment of Anesthesiology, Nordsjællands Hospital, University of Copenhagen, 3400, Hilleroed, Denmark.
Heidi KnudsenDepartment of Anesthesiology, Herlev Hospital, University of Copenhagen, 2730, Herlev, Denmark.
Louise B GrodeDepartment of Anesthesiology, Hospital of Horsens, 8700, Horsens, Denmark.
Dorthe OvergaardResearch Unit, Nordsjællands Hospital, and Department of Nursing, Metropolitan University College, 2200, Copenhagen, Denmark.
University of Copenhagen · DKHerlev Hospital · DKMetropolitan University College · DKNordsjællands Hospital · DKRegional Hospital Horsens · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this randomized controlled trial (RCT) was to test the effectiveness of a post-ICU recovery program compared to standard care during the first year after ICU discharge.

methodsA pragmatic, non-blinded, multicenter, parallel-group RCT was conducted between December 2012 and December 2015, at ten intensive care units (ICUs) in Denmark. We randomly assigned 386 adult patients (≥18 years) after receiving mechanical ventilation (≥48 h) to standard care (SC) plus a nurse-led intensive care recovery program or standard care alone after ICU discharge (190 intervention, 196 SC). Primary outcome was health-related quality of life (HRQOL) at 12 months. Secondary outcomes were sense of coherence (SOC), anxiety, depression, and post-traumatic stress disorder (PTSD) assessed at 3 and 12 months after ICU discharge including utilization of healthcare services at 12 months.

resultsAt 12 months, we found no differences in HRQOL between groups (mean difference in the Physical Component Summary score, 1.41 [95 % CI, -1.53 to 4.35; p = 0.35] (n = 235); and in the Mental Component Summary score, 1.92 [95 % CI, -1.06 to 4.90; p = 0.11] (n = 235). No differences were found on self-reported SOC (p = 0.63), anxiety (p = 0.68), depression (p = 0.67), PTSD (p = 0.27), or the utilization of healthcare services including rehabilitation. We found a difference on anxiety, when a cut-off point ≥11 was applied, in per protocol analysis of complete cases at 3 months favoring the intervention (8.8 % vs. 16.2 %, p = 0.04).

conclusionsThe tested recovery program was not superior to standard care during the first 12 months post-ICU.

trial registrationThe trial is registered at Clinicaltrials.gov, identification no. NCT01721239.

Indexed as

Practice Patterns, Nurses'Quality of LifeSense of CoherenceAgedCritical IllnessFemaleHumansIntensive Care UnitsMiddle AgedNursing ResearchOutcome Assessment, Health CareProgram EvaluationRespiration, ArtificialSurvivorsTime FactorsAftercareFollow-upICU clinicIntensive careMulticenter randomized clinical controlled trialRehabilitation

Identifiers

PMID27695894
OpenAlexW2527121601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.