ArticleArchives of medical science : AMS2016
Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children.
Article in Archives of medical science : AMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Influence of DNA-Polymorphisms in Selected Circadian Clock Genes on Clock Gene Expression in Subjects from the General Population and Their Association with Sleep Duration.Medicina (Kaunas, Lithuania) · 2022Article
- Effect of black ginseng and silkworm supplementation on obesity, the transcriptome, and the gut microbiome of diet-induced overweight dogs.Scientific reports · 2021Article
- Urate crystal deposition in hyperuricemic children: a dual energy computed tomography study.Archives of medical science : AMS · 2021Article
- The association of endothelin-1 gene polymorphism and its plasma levels with hypertension and coronary atherosclerosis.Archives of medical science : AMS · 2021Article
- Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents.Archives of medical science : AMS · 2019Article
- Association of common polymorphisms in theArchives of medical science : AMS · 2018Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObesity is a chronic, complex, and multifactorial disease, characterized by excess body fat. Diverse studies of the human genome have led to the identification of susceptibility genes that contribute to obesity. However, relatively few studies have addressed specifically the association between the level of expression of these genes and obesity. MATERIAL AND
methodsWe studied 160 healthy and obese unrelated Mexican children aged 6 to 14 years. We measured the transcriptional expression of 20 genes associated with obesity, in addition to the biochemical parameters, in peripheral white blood cells. The detection of mRNA levels was performed using the OpenArray Real-Time PCR System (Applied Biosystems).
resultsObese children exhibited higher values of fasting glucose (
conclusionsOur results suggest that changes in the expression level of the studied genes are involved in biological processes implicated in the development of childhood obesity. Our study contributes new perspectives for a better understanding of biological processes involved in obesity. The protocol was approved by the National Committee and Ethical Committee Board from the Mexican Social Security Institute (IMSS) (IMSS FIS/IMSS/PRIO/10/011).
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