Evidence map›Paper›PMID 27695350›Full record

ArticleJournal of asthma and allergy2016

Study of the correlations between fractional exhaled nitric oxide in exhaled breath and atopic status, blood eosinophils, FCER2 mutation, and asthma control in Vietnamese children.

Hanh Nguyen-Thi-Bich, Huong Duong-Thi-Ly, Vu Thi Thom, Nhung Pham-Thi-Hong, Long Doan Dinh, Huong Le-Thi-Minh, Timothy John Craig, Sy Duong-Quy

Open access · goldAbstract read
In one paragraph

Article in Journal of asthma and allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Trial
  4. Article
  5. Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hanh Nguyen-Thi-BichDepartment of Immunology, Allergology, and Rheumatology, National Hospital of Pediatrics, Hanoi, Vietnam.
Huong Duong-Thi-LySchool of Medicine and Pharmacy, Vietnam National University Hanoi, Vietnam.
Vu Thi ThomSchool of Medicine and Pharmacy, Vietnam National University Hanoi, Vietnam.
Nhung Pham-Thi-HongSchool of Medicine and Pharmacy, Vietnam National University Hanoi, Vietnam.
Long Doan DinhSchool of Medicine and Pharmacy, Vietnam National University Hanoi, Vietnam.
Huong Le-Thi-MinhDepartment of Immunology, Allergology, and Rheumatology, National Hospital of Pediatrics, Hanoi, Vietnam.
Timothy John CraigDepartment of Medicine, Penn State University, Hershey, PA, USA.
Sy Duong-QuyDepartment of Medicine, Penn State University, Hershey, PA, USA; Department of Respiratory Diseases, Lam Dong Medical College, Dalat, Vietnam.
Vietnam National University, Hanoi · VNNational Hospital of Pediatrics · VNPenn State Milton S. Hershey Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFractional exhaled nitric oxide (FENO) is a biomarker of airway inflammation in asthma. The measurement of FENO is utilized to assist in the diagnosis and treatment of children with asthma, especially for those treated with inhaled corticosteroids.

objectivesThe aims of this study were to evaluate the correlations between FENO and atopic status, blood eosinophil levels, FCER2 mutation, and asthma control in Vietnamese children. SUBJECTS AND

methodsThis was a prospective and descriptive study approved by the local Ethical Board. All children with uncontrolled asthma, seen in the National Hospital of Pediatrics (Hanoi, Vietnam), were included. Exhaled breath FENO, blood eosinophils, skin prick test, total IgE, asthma control test (ACT), and FCER2 gene polymorphism were performed at inclusion. They were followed up at 3 months to evaluate clinical status, FENO levels, and ACT.

resultsForty-two children with uncontrolled asthma with a mean age of 10±3 years (6-16 years) were included. The male/female ratio was 2.5/1. The mean FENO levels were 26±25 ppb. FENO was significantly higher in patients with a positive skin prick test for respiratory allergens (

conclusionThe measurement of FENO levels is a useful and feasible tool to predict clinical, biological, and asthma control in Vietnamese children.

Indexed as

asthmaeosinophilsFCER2FENOICSnitric oxide

Identifiers

PMID27695350
PMCPMC5029846
OpenAlexW2518728679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.