ReviewInternational journal of nanomedicine
Demineralization-remineralization dynamics in teeth and bone.
Review in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06834464 (Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on Remineralization and Color Change of White Spot Lesions In Children), which is not on this map. Cited by 271 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on Remineralization and Color Change of White Spot Lesions In Children: A Randomized Control Study.
Who cites it
271 citing papers in PubMed, 2 syntheses or guidelines pooled it, 654 citations in OpenAlex.
- Impact of Gastroesophageal Reflux Disease on Salivary Flow Rate, pH and Buffer Capacity: A Systematic Review and Meta-Analysis.Journal of oral rehabilitation · 2025Pooled it
- Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Pooled it
- Effects of calcium-containing solutions on fluorescence-detectable plaque area and enamel mineral volume: an in vitro and exploratory clinical study.BMC oral health · 2026Trial
- Comparative assessment of four treatments for post orthodontic white spot lesions over a 24-month period: a randomized controlled clinical trial.BMC oral health · 2026Trial
- A 12-months randomized clinical trial comparing fluoride-based remineralising protocols on post-orthodontic initial caries lesions.Clinical oral investigations · 2025Trial
- The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Effects of bleaching agents containing nano-hydroxyapatite on sound and demineralized enamel: an in vitro study.Odontology · 2026Article
- Multiple forensic insights for human identification using single teeth with applicability to advanced postmortem remains.Scientific reports · 2026Article
- Effect of Fluoride Varnishes Containing Casein Phosphopeptide-amorphous Calcium Phosphate on Primary Enamel Microhardness: AnInternational journal of clinical pediatric dentistry · 2026Article
- Foxq1-Wnt5a Axis Activation in Dental Papilla Stem Cells Promotes Odontogenesis on Acellular Matrix: A Laboratory Investigation.International endodontic journal · 2026Article
- Bioinspired layer-by-layer nanoengineering for dental hard tissue regeneration and caries prevention.Journal of nanobiotechnology · 2026Article
- The Potential ofJournal of clinical medicine · 2026Review
- Enamel Remineralizing Agents: State of the Art.Materials (Basel, Switzerland) · 2026Review
- Erosive Potential of Commercially Available Cannabis Beverages.Clinical and experimental dental research · 2026Article
- Comparative Evaluation of Remineralization Efficacy of Nanosilver Fluoride and Xylitol-coated Calcium Phosphate Fluoride Varnishes Using Atomic Force Microscopy and DIAGNOdent®: AnInternational journal of clinical pediatric dentistry · 2026Article
- The Effects of Exercise on Fluorosis: A Comprehensive Multisystem Review.Veterinary sciences · 2026Review
- Assessment of the remineralizing potential of nano-bioactive glass, nano-hydroxyapatite, and sodium fluoride on artificial carious lesions in primary teeth.BMC oral health · 2026Article
- Preparation of amorphous calcium phosphate nanoparticles using small organic molecules for biomimetic mineralization of dentin.RSC advances · 2026Article
- Evaluation of the remineralization effect of goat milk compared to cow milk and artificial saliva on demineralized enamel (an in vitro study).Odontology · 2026Article
- Fish bone and chitosan based nanogels in green dentistry: sustainable and eco-friendly biomimetic remineralizing agents for early enamel caries.BMC oral health · 2026Article
211 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization. Then, the role of calcium and phosphate ions in the maintenance of teeth and bone health is described. Throughout the life, teeth and bone are at risk of demineralization, with particular emphasis on teeth, due to their anatomical arrangement and location. Teeth are exposed to food, drink, and the microbiota of the mouth; therefore, they have developed a high resistance to localized demineralization that is unmatched by bone. The mechanisms by which demineralization-remineralization process occurs in both teeth and bone and the new therapies/technologies that reverse demineralization or boost remineralization are also scrupulously discussed. Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues. Turning these new technologies to products and practices would improve health care worldwide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.