Evidence map›Paper›PMID 27695325›Full record

ArticleInternational journal of nanomedicine

Surface biofunctionalized CdS and ZnS quantum dot nanoconjugates for nanomedicine and oncology: to be or not to be nanotoxic?

Alexandra Ap Mansur, Herman S Mansur, Sandhra M de Carvalho, Zélia Ip Lobato, Maria Imc Guedes, Maria F Leite

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Composition-Tunable Optical Properties of ZnNanoscale research letters · 2017
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Alexandra Ap MansurCenter of Nanoscience, Nanotechnology, and Innovation-CeNano I, Department of Metallurgical and Materials Engineering.
Herman S MansurCenter of Nanoscience, Nanotechnology, and Innovation-CeNano I, Department of Metallurgical and Materials Engineering.
Sandhra M de CarvalhoCenter of Nanoscience, Nanotechnology, and Innovation-CeNanoI, Department of Metallurgical and Materials Engineering; Department of Preventive Veterinary Medicine, Veterinary School; Department of Physiology and Biophysics, ICB, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Zélia Ip LobatoDepartment of Preventive Veterinary Medicine, Veterinary School.
Maria Imc GuedesDepartment of Preventive Veterinary Medicine, Veterinary School.
Maria F LeiteDepartment of Physiology and Biophysics, ICB, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Centre de Nanosciences et de Nanotechnologies · FRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, for the first time, we demonstrated that novel biofunctionalized semiconductor nanomaterials made of Cd-containing fluorescent quantum dot nanoconjugates with the surface capped by an aminopolysaccharide are not biologically safe for clinical applications. Conversely, the ZnS-based nanoconjugates proved to be noncytotoxic, considering all the parameters investigated. The results of in vitro cytotoxicity were remarkably dependent on the chemical composition of quantum dot (CdS or ZnS), the nature of the cell (human cancerous and embryonic types), and the concentration and time period of exposure to these nanomaterials, caused by the effects of Cd

Indexed as

NanomedicineNeoplasmsToxicity TestsAnimalsCadmium CompoundsCell Line, TumorCell SurvivalHumansLiverMaleMiceNanoconjugatesQuantum DotsSulfidesSurface PropertiesZinc CompoundsCadmium Compoundscadmium sulfideNanoconjugatesSulfidesZinc Compoundszinc sulfidebionanoconjugatesfluorescent nanoparticlesnanoprobesnanotoxicitysemiconductor quantum dots

Identifiers

PMID27695325
PMCPMC5028090
OpenAlexW2519352825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.