ArticleInternational journal of nanomedicine
Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drugs.
Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Multifaceted boron nitride nanomaterials: a comprehensive review of synthesis, property engineering and multidisciplinary applications.RSC advances · 2026Review
- Biodegradation of hydroxylated boron nitride nanoplatelets, their toxic effect and drug delivery application.RSC advances · 2024Article
- Biomimetic Boron Nitride Nanoparticles for Targeted Drug Delivery and Enhanced Antitumor Activity.Pharmaceutics · 2023Article
- Stimuli-Responsive Boron-Based Materials in Drug Delivery.International journal of molecular sciences · 2023Review
- Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer's Disease Treatment.International journal of molecular sciences · 2022Article
- Stability of Boron Nitride Nanosphere Dispersions in the Presence of Polyelectrolytes.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Specific Ion Effects on Aggregation and Charging Properties of Boron Nitride Nanospheres.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Cancer Cell-Membrane Biomimetic Boron Nitride Nanospheres for Targeted Cancer Therapy.International journal of nanomedicine · 2021Article
- Article
- Non-cytotoxic hydroxyl-functionalized exfoliated boron nitride nanoflakes impair the immunological function of insect haemocytes in vivo.Scientific reports · 2019Article
- Fullerene-like boron nitride cages BxNy (x + y = 28): stabilities and electronic properties from density functional theory computation.Journal of molecular modeling · 2019Article
- Synthesis, Functionalization, and Bioapplications of Two-Dimensional Boron Nitride Nanomaterials.Frontiers in bioengineering and biotechnology · 2019Review
- Hexagonal Boron Nitrides (White Graphene): A Promising Method for Cancer Drug Delivery.International journal of nanomedicine · 2019Review
- Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage-targeted drug delivery.International journal of nanomedicine · 2019Article
- Hexagonal Boron Nitride Functionalized with Au Nanoparticles-Properties and Potential Biological Applications.Nanomaterials (Basel, Switzerland) · 2018Article
- pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery.International journal of nanomedicine · 2018Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With its unique physical and chemical properties and structural similarity to carbon, boron nitride (BN) has attracted considerable attention and found many applications. Biomedical applications of BN have recently started to emerge, raising great hopes in drug and gene delivery. Here, we developed a targeted anticancer drug delivery system based on folate-conjugated BN nanospheres (BNNS) with receptor-mediated targeting. Folic acid (FA) was successfully grafted onto BNNS via esterification reaction. In vitro cytotoxicity assay showed that BNNS-FA complexes were non-toxic to HeLa cells up to a concentration of 100 μg/mL. Then, doxorubicin hydrochloride (DOX), a commonly used anticancer drug, was loaded onto BNNS-FA complexes. BNNS-FA/DOX complexes were stable at pH 7.4 but effectively released DOX at pH 5.0, which exhibited a pH sensitive and sustained release pattern. BNNS-FA/DOX complexes could be recognized and specifically internalized by HeLa cells via FA receptor-mediated endocytosis. BNNS-FA/DOX complexes exhibited greater cytotoxicity to HeLa cells than free DOX and BNNS/DOX complexes due to the increased cellular uptake of DOX mediated by the FA receptor. Therefore, BNNS-FA complexes had strong potential for targeted cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.