Evidence map›Paper›PMID 27695291›Full record

ArticleDrug design, development and therapy2016

Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP.

Teresa Esposito, Jean Marc Lobaccaro, Maria Grazia Esposito, Vincenzo Monda, Antonietta Messina, Giuseppe Paolisso, Bruno Varriale, Marcellino Monda, Giovanni Messina

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Quantitative Multi-Parameter MRI Evaluation of Hashimoto's Thyroiditis Changes After Dietary Interventions.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Trial
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Teresa EspositoDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine; Laboratory of Molecular Biology and Genetics, Department of Experimental Medicine, Second University of Naples, Naples, Italy.
Jean Marc LobaccaroUMR, Clermont Université, Centre de Recherche en Nutrition Humaine d'Auvergne, Aubière Cedex, France.
Maria Grazia EspositoComplex Surgery Unit, Evangelic Hospital Villa Betania.
Vincenzo MondaDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine.
Antonietta MessinaDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine.
Giuseppe PaolissoDepartment of Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell'Invecchiamento, Second University of Naples, Naples.
Bruno VarrialeLaboratory of Molecular Biology and Genetics, Department of Experimental Medicine, Second University of Naples, Naples, Italy.
Marcellino MondaDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine.
Giovanni MessinaDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Laboratory of Molecular Genetics · PLCentre de Recherche en Nutrition Humaine d'Auvergne · FRUniversity of Foggia · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thyroid is one of the metabolism regulating glands. Its function is to determine the amount of calories that the body has to burn to maintain normal weight. Thyroiditides are inflammatory processes that mainly result in autoimmune diseases. We have conducted the present study in order to have a clear picture of both autoimmune status and the control of body weight. We have evaluated the amount of either thyroid hormones, or antithyroid, or anti-microsomal, or anti-peroxidase antibodies (Abs) in patients with high amounts of Abs. In a diet devoid of carbohydrates (bread, pasta, fruit, and rice), free from goitrogenic food, and based on body mass index, the distribution of body mass and intracellular and extracellular water conducted for 3 weeks gives the following results: patients treated as above showed a significant reduction of antithyroid (-40%,

Indexed as

Diet, Carbohydrate-RestrictedAutoantibodiesAutoimmune DiseasesCarrier ProteinsHumansOverweightThyroid GlandThyroiditis, AutoimmuneTranscription FactorsAutoantibodiesCarrier ProteinsTranscription Factorslow-carbohydrate dietprotein dietthyroid autoantibodiesthyroid hormonesthyroiditis

Identifiers

PMID27695291
PMCPMC5028075
OpenAlexW2519323861

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.