ReviewClinical ophthalmology (Auckland, N.Z.)2016
Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature.
Review in Clinical ophthalmology (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03760770 (Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients
Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Ultrahigh-resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing.Acta ophthalmologica · 2019Trial
- Topical losartan to prevent stromal scarring during post-cross-linking infection in pediatric keratoconus: A case report.American journal of ophthalmology case reports · 2026Article
- Evaluation of corneal stromal demarcation line depth after corneal collagen cross-linking with two different UV energy levels in keratoconus: a comparative study using AS-OCT andInternational journal of ophthalmology · 2026Article
- A bioequivalent cornea cross-linking method using photo-initiators LAP and visible light.Materials today. Bio · 2025Article
- Evaluating corneal cross-linking using Stress-Strain Index maps: a finite element study.Journal of the Royal Society, Interface · 2025Article
- Assessing UVA and Laser-Induced Crosslinking via Brillouin Microscopy.Journal of biophotonics · 2025Article
- Influencing Factors in Corneal Densitometry Recovery After Accelerated Cross-Linking for Keratoconus.Journal of ophthalmology · 2025Article
- Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions: theoretical basis.International journal of ophthalmology · 2024Review
- Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography.Biomedical optics express · 2023Article
- Article
- Long-term visual, refractive, tomographic and aberrometric outcomes of corneal collagen crosslinking (CXL) with or without hypoosmolar riboflavin solution in the treatment of progressive keratoconus patients with thin corneas.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Adverse events after riboflavin/UV-A corneal cross-linking: a literature review.International ophthalmology · 2022Review
- Evaluation of the Relationship Between the Changes in the Corneal Biomechanical Properties and Changes in the Anterior Segment OCT Parameters Following Customized Corneal Cross-Linking.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Are changes in visual acuity and astigmatism after corneal cross-linking (CXL) in keratoconus predictable?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Corneal Cross-Linking as Treatment in Pediatric Keratoconus: Comparison of Two Protocols.Journal of ophthalmology · 2021Article
- Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression.International journal of ophthalmology · 2020Article
- Comparative Results of "Epi-Off" Conventional versus "Epi-Off" Accelerated Cross-Linking Procedure at 5-year Follow-Up.Journal of ophthalmology · 2020Article
- Correlation of central and peripheral keratometric parameters after corneal collagen cross-linking in keratoconus patients.International ophthalmology · 2019Article
- Standard cross-linking versus photorefractive keratectomy combined with accelerated cross-linking for keratoconus management: a comparative study.Acta ophthalmologica · 2019Article
- Correlation between corneal stromal demarcation line depth and topographic outcomes after two pulsed-light-accelerated crosslinking protocols.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia, which is able to strengthen corneal tissue reforming new covalent bonds. Subjective and objective results following this method seem to be promising. In recent years, newer CXL protocols have been developed to perform more effective and less invasive procedures. The increasing diffusion of CXL in the corneal ectatic disease has increased the need to have actual indices regarding the efficacy of the treatment. Evaluation of demarcation line (DL), a transition zone between the cross-linked anterior corneal stroma and the untreated posterior corneal stroma, is considered a measurement of the depth of CXL treatment into the stroma. Some evidence in the literature emphasize that DL could be a measure of effectiveness of the CXL. On the contrary, some authors believe that the "the deeper, the better" principle is rather a simplistic approach for interpreting the clinical importance of the corneal stromal DL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.