ArticlePharmacognosy research
Wound Healing Activity of Silibinin in Mice.
Article in Pharmacognosy research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Silibinin-Loaded Proniosomal Gel for Cutaneous Application: Pharmaco-Technical Characterization and In Vitro-In Ovo Biocompatibility.Gels (Basel, Switzerland) · 2026Article
- Review
- Design and Optimization of Pullulan-Isononanoate Films with Bioactive-Loaded Liposomes for Potential Biomedical Use.Polymers · 2026Article
- Wound healing potential ofJournal of traditional and complementary medicine · 2023Article
- Potential use of the Asteraceae family as a cure for diabetes: A review of ethnopharmacology to modern day drug and nutraceuticals developments.Frontiers in pharmacology · 2023Review
- Evaluation of Wound Healing and Anti-Inflammatory Activities of 80% Methanol Crude Extract and Solvent Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Novel Pullulan/Gellan Gum Bilayer Film as a Vehicle for Silibinin-Loaded Nanocapsules in the Topical Treatment of Atopic Dermatitis.Pharmaceutics · 2022Article
- Wound Healing Activity of 80% Methanolic Crude Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2022Article
- Evaluation of Wound Healing and Anti-Inflammatory Activity of Hydroalcoholic Leaf Extract ofClinical, cosmetic and investigational dermatology · 2022Article
- In-vivo Wound Healing and Anti-Inflammatory Activity of the Solvent Fraction ofJournal of experimental pharmacology · 2022Article
- Evaluation of Wound Healing Activity of Methanolic Crude Extract and Solvent Fractions of the Leaves ofJournal of experimental pharmacology · 2021Article
- Article
- A topical ointment formulation containing leaves' powder ofVeterinary world · 2020Article
- Modulation of Skin Inflammatory Response by Active Components of Silymarin.Molecules (Basel, Switzerland) · 2018Article
- Use of Some Asteraceae Plants for the Treatment of Wounds: From Ethnopharmacological Studies to Scientific Evidences.Frontiers in pharmacology · 2018Review
- Adjuvant effect of oral Silymarin on patients' wound healing process caused by thermal injuries.Caspian journal of internal medicine · 2018Article
- Evaluation of wound healing activity of the crude extract and solvent fractions ofScars, burns & healingArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilibinin is a semi-purified fraction of silymarin contained in milk thistle (
objectiveThis study investigates wound healing activity of silibinin topical formulation. MATERIALS AND
methodsWound healing activity of 0.2% silibinin gel was assessed by incision and excision wound models in mice. Animals were divided into gel base, silibinin gel, and Mega Heal gel
resultsApplication of 0.2% silibinin hydrogel for 8 days led to 56.3% wound contraction compared to 64.6% using standard Mega Heal gel with a subsequent increase in hydroxyproline content, which was significantly higher (
conclusionHere, we show potent wound healing activity of silibinin hydrogel formulation. SUMMARY: 0.2% silibinin hydrogel showed potent wound healing activity in incision and excision wound models in mice.
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