Evidence map›Paper›PMID 27695205›Full record

ArticleRadiation physics and chemistry (Oxford, England : 1993)2016

Gamma and Ion-Beam Irradiation of DNA: Free Radical Mechanisms, Electron Effects, and Radiation Chemical Track Structure.

Michael D Sevilla, David Becker, Anil Kumar, Amitava Adhikary

Abstract read
In one paragraph

Article in Radiation physics and chemistry (Oxford, England : 1993), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Radiation and DNA Origami Nanotechnology: Probing Structural Integrity at the Nanoscale.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Development of Live AttenuatedFrontiers in immunology · 2022
    Article
  11. Low-Energy Electron Damage to Condensed-Phase DNA and Its Constituents.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Substituent Effect in the Cation Radicals of Monosubstituted Benzenes.International journal of molecular sciences · 2021
    Article
  14. Radiation-InactivatedFrontiers in immunology · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Reaction of Electrons with DNA: Radiation Damage to Radiosensitization.International journal of molecular sciences · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael D SevillaDepartment of Chemistry, Oakland University, Rochester, MI - 48309, USA.
David BeckerDepartment of Chemistry, Oakland University, Rochester, MI - 48309, USA.
Anil KumarDepartment of Chemistry, Oakland University, Rochester, MI - 48309, USA.
Amitava AdhikaryDepartment of Chemistry, Oakland University, Rochester, MI - 48309, USA.

Funding

RADIOPROTECTION OF DNA BY THIOLS--OXYGEN AND LET EFFECTSR01CA045424 · NCI · OAKLAND UNIVERSITY · PI SEVILLA, MICHAEL DOUGLAS · 1987 to 2021
$4.2M
NCI NIH HHS R01 CA045424United States NCI
6 · The paper itself

Abstract

The focus of our laboratory's investigation is to study the direct-type DNA damage mechanisms resulting from γ-ray and ion-beam radiation-induced free radical processes in DNA which lead to molecular damage important to cellular survival. This work compares the results of low LET (γ-) and high LET (ion-beam) radiation to develop a chemical track structure model for ion-beam radiation damage to DNA. Recent studies on protonation states of cytosine cation radicals in the N1-substituted cytosine derivatives in their ground state and 5-methylcytosine cation radicals in ground as well as in excited state are described. Our results exhibit a radical signature of excitations in 5-methylcytosine cation radical. Moreover, our recent theoretical studies elucidate the role of electron-induced reactions (low energy electrons (LEE), presolvated electrons (e

Indexed as

density functional theory (DFT)DNA-radicalselectron spin resonance (ESR)ion-beam radiationlow energy electrons (LEE)γ-radiation

Identifiers

PMID27695205
PMCPMC5040349

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.