ArticleNature immunology2016
Suppression by T
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
132 citing papers in PubMed, 228 citations in OpenAlex.
- Lymphoid Aggregates in the CNS of Progressive Multiple Sclerosis Patients Lack Regulatory T Cells.Frontiers in immunology · 2019Trial
- TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro.Cellular & molecular immunology · 2026Article
- Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting T regulatory cells.Journal of leukocyte biology · 2026Article
- IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2Nature communications · 2026Article
- Bioengineered anti-EpCAM-guided exosome nanocarriers delivering Foxp3 agonist butyrate achieve tissue-specific immunomodulation in autoimmune Sjögren's syndrome.Journal of nanobiotechnology · 2026Article
- The role of T cells in influenza infection and vaccination.Virologica Sinica · 2026Review
- Stability and progressive differentiation of TNature immunology · 2026Article
- Elevated levels of nitrotyrosine-modified protein adducts and their association with the severity of primary sjogren's syndrome and secondary sjogren's syndrome with rheumatoid arthritis in Taiwanese Patients.Clinical rheumatology · 2026Article
- An influenza HA mRNA-LNP vaccine induces potent responses in newborn nonhuman primates that enhance protection from challenge.NPJ vaccines · 2025Article
- Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity.Nature immunology · 2025Article
- Tertiary Lymphoid Structures in Human Melanoma: Molecular Mechanisms and Therapeutic Opportunities.Cells · 2025Review
- The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice.Blood · 2025Article
- Emerging role of follicular regulatory T-cells in neuroimmunological disorders.Current opinion in immunology · 2025Review
- Article
- Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells.Nature communications · 2025Article
- Regulatory T cell epitope content in human antibodies decreases during maturation.Frontiers in immunology · 2025Article
- Differential Diagnosis of Tuberculosis and Sarcoidosis by Immunological Features Using Machine Learning.Diagnostics (Basel, Switzerland) · 2024Article
- IL-12 drives the differentiation of human T follicular regulatory cells.Science immunology · 2024Article
- Article
- Follicular Helper T Cells and Follicular Regulatory T Cells Involved in Immune Disorders of Idiopathic Membranous Nephropathy.Indian journal of pediatrics · 2024Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Peter T SageDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Noga Ron-HarelDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Vikram R JunejaDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Debattama R SenDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-0947-8284
Seth MaleriDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Waradon SungnakEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Vijay K KuchrooEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
W Nicholas HainingDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Nicolas ChevrierFAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA.
Marcia HaigisDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Arlene H SharpeDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USHarvard University · USBroad Institute · USDana-Farber Cancer Institute · US
Funding
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5MThe Slamf3, Slamf5, and Slamf6 receptor-induced pathways to murine lupusP01AI065687 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHARPE, ARLENE H. · 2006 to 2016
$14.7MVASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7MIN VIVO ROLE OF CTLA-4 IN COSTIMULATION AND AUTOIMMUNITYR01AI040614 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 1997 to 2018
$6.3MIn Vivo Function of the B7 Family of CostimulatorsR37AI038310 · NIAID · HARVARD MEDICAL SCHOOL · PI SHARPE, ARLENE H. · 2006 to 2015
$4.1MNHLBI NIH HHS T32 HL007627NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI065687NIAID NIH HHS R01 AI040614NIAID NIH HHS R37 AI038310
Abstract
Follicular regulatory T cells (T
Indexed as
Immune ToleranceAnimalsAntibody FormationB-Lymphocyte SubsetsCells, CulturedEpigenesis, GeneticForkhead Transcription FactorsGerminal CenterInterleukin-21Interleukin-21 Receptor alpha SubunitInterleukinsMiceMice, Inbred C57BLMice, KnockoutT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouseIl21r protein, mouseInterleukin-21Interleukin-21 Receptor alpha SubunitInterleukins
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.