Observational studyScientific reports2016
The impact of non-severe burn injury on cardiac function and long-term cardiovascular pathology.
Observational study in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Determination of Burn Size in Mouse Models of Burn Injury: A Scoping Review of Studies Leveraging Scald and Contact Burns.Journal of burn care & research : official publication of the American Burn Association · 2025Pooled it
- Neuropathic agents in the management of pruritus in burn injuries: a systematic review and meta-analysis.Trauma surgery & acute care open · 2021Pooled it
- Evolving Burn Care: The Transition from Life Preservation to Life Restoration-A Narrative Review.Journal of clinical medicine · 2026Review
- Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury.Journal of proteome research · 2024Article
- Attrition of Well-Healed Burn Survivors to a 6-Month Community-Based Exercise Program: A Retrospective Evaluation.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Review
- Cardiometabolic disease risk markers are increased following burn injury in children.Frontiers in public health · 2023Article
- Current understanding of the chronic stress response to burn injury from human studies.Burns & trauma · 2023Review
- Systemic long-term metabolic effects of acute non-severe paediatric burn injury.Scientific reports · 2022Article
- Frontal lobe hemodynamics detected by functional near-infrared spectroscopy during head-up tilt table tests in patients with electrical burns.Frontiers in human neuroscience · 2022Article
- Status of adult inpatient burn rehabilitation in Europe: Are we neglecting metabolic outcomes?Burns & trauma · 2021Article
- Article
- Cats with thermal burn injuries from California wildfires show echocardiographic evidence of myocardial thickening and intracardiac thrombi.Scientific reports · 2020Article
- Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response.Frontiers in immunology · 2020Article
- A Severe Complication of Myocardial Dysfunction Post Radiofrequency Ablation Treatment of Huge Hepatic Hemangioma: A Case Report and Literature Review.Open medicine (Warsaw, Poland) · 2019Article
- Understanding acute burn injury as a chronic disease.Burns & trauma · 2019Review
- Long-term mental health outcomes after unintentional burns sustained during childhood: a retrospective cohort study.Burns & trauma · 2018Article
- Troponins and echocardiography: role in detecting myocardial injury in burn patients.Therapeutic advances in cardiovascular diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe burn injury significantly affects cardiovascular function for up to 3 years. However, whether this leads to long-term pathology is unknown. The impact of non-severe burn injury, which accounts for over 80% of admissions in developed countries, has not been investigated. Using a rodent model of non-severe burn injury with subsequent echocardiography we showed significantly increased left ventricular end systolic diameter (LVESD) and ventricular wall thickness at up to 3 months post-injury. Use of propranolol abrogated the changes in cardiac measures observed. Subsequently we investigated changes in a patient cohort with non-severe injury. Echocardiography measured at baseline and at 3 months post-injury showed increased LVESD at 3 months and significantly decreased posterior wall diameter. Finally, 32 years of Western Australian hospital records were used to investigate the incidence of cardiovascular disease admissions after burn injury. People who had experienced a burn had increased hospital admissions and length of stay for cardiovascular diseases when compared to a matched uninjured cohort. This study presents animal, patient and population data that strongly suggest non-severe burn injury has significant effects on cardiovascular function and long-term morbidity in some burn patients. Identification of patients at risk will promote better intervention and outcomes for burn patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.